bis-(5-azido-2-chloro-benzyl)-[1-(3-azido-phenyl)-ethyl]-amine

Base Information

• Chemical Name: bis-(5-azido-2-chloro-benzyl)-[1-(3-azido-phenyl)-ethyl]-amine
• CAS No.: 443299-20-5
• Molecular Formula: C₂₂H₁₈Cl₂N₁₀
• Molecular Weight: 493.358
• Mol file: 443299-20-5.mol

Synonyms:bis-(5-azido-2-chloro-benzyl)-[1-(3-azido-phenyl)-ethyl]-amine

Chemical Property of bis-(5-azido-2-chloro-benzyl)-[1-(3-azido-phenyl)-ethyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis-(5-azido-2-chloro-benzyl)-[1-(3-azido-phenyl)-ethyl]-amine

There total 5 articles about bis-(5-azido-2-chloro-benzyl)-[1-(3-azido-phenyl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-(3-azidophenyl)ethylamine (443299-17-0) + 4-azido-1-chloro-2-iodomethyl-benzene (443299-19-2) → bis-(5-azido-2-chloro-benzyl)-[1-(3-azido-phenyl)-ethyl]-amine (443299-20-5)

Guidance literature:

With sodium carbonate; In acetonitrile; for 16h; Heating;

DOI:10.1016/j.tetlet.2007.03.087

Reference yield:

5-azido-2-chlorobenzyl chloride (902140-48-1) → bis-(5-azido-2-chloro-benzyl)-[1-(3-azido-phenyl)-ethyl]-amine (443299-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / NaI / acetone / 12 h / 25 °C

2: 60 percent / Na₂CO₃ / acetonitrile / 16 h / Heating

With sodium carbonate; sodium iodide; In acetone; acetonitrile;

DOI:10.1016/j.tetlet.2007.03.087

Reference yield:

5-azido-2-chlorobenzyl alcohol (902140-45-8) → bis-(5-azido-2-chloro-benzyl)-[1-(3-azido-phenyl)-ethyl]-amine (443299-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / SOCl₂ / CH₂Cl₂ / 3 h / 0 °C

2: 99 percent / NaI / acetone / 12 h / 25 °C

3: 60 percent / Na₂CO₃ / acetonitrile / 16 h / Heating

With thionyl chloride; sodium carbonate; sodium iodide; In dichloromethane; acetone; acetonitrile;

DOI:10.1016/j.tetlet.2007.03.087

upstream raw materials:

1-(3-azidophenyl)ethylamine

4-azido-1-chloro-2-iodomethyl-benzene

5-azido-2-chlorobenzyl chloride

5-azido-2-chlorobenzyl alcohol

Downstream raw materials:

C₆₃H₅₇Cl₂N₁₀P₃