[(7,8-bis-benzyloxymethyl-3-methyl-2-aza-bicyclo[2.2.2]oct-5-en-2-yl)-phenyl-methylene]-(1-methoxymethyl-2-methyl-propyl)-amine

Base Information

Chemical Name:[(7,8-bis-benzyloxymethyl-3-methyl-2-aza-bicyclo[2.2.2]oct-5-en-2-yl)-phenyl-methylene]-(1-methoxymethyl-2-methyl-propyl)-amine
CAS No.:873545-87-0
Molecular Formula:C₃₇H₄₆N₂O₃
Molecular Weight:566.784
Hs Code.:

Synonyms:[(7,8-bis-benzyloxymethyl-3-methyl-2-aza-bicyclo[2.2.2]oct-5-en-2-yl)-phenyl-methylene]-(1-methoxymethyl-2-methyl-propyl)-amine

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Chemical Property of [(7,8-bis-benzyloxymethyl-3-methyl-2-aza-bicyclo[2.2.2]oct-5-en-2-yl)-phenyl-methylene]-(1-methoxymethyl-2-methyl-propyl)-amine

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Technology Process of [(7,8-bis-benzyloxymethyl-3-methyl-2-aza-bicyclo[2.2.2]oct-5-en-2-yl)-phenyl-methylene]-(1-methoxymethyl-2-methyl-propyl)-amine

There total 4 articles about [(7,8-bis-benzyloxymethyl-3-methyl-2-aza-bicyclo[2.2.2]oct-5-en-2-yl)-phenyl-methylene]-(1-methoxymethyl-2-methyl-propyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873545-85-8
{5-hydroxymethyl-2-[(1-methoxymethyl-2-methyl-propylimino)-phenyl-methyl]-3-methyl-2-aza-bicyclo[2.2.2]oct-7-en-6-yl}-methanol

: 100-39-0
benzyl bromide

: 873545-87-0
[(7,8-bis-benzyloxymethyl-3-methyl-2-aza-bicyclo[2.2.2]oct-5-en-2-yl)-phenyl-methylene]-(1-methoxymethyl-2-methyl-propyl)-amine

Guidance literature:: {5-hydroxymethyl-2-[(1-methoxymethyl-2-methyl-propylimino)-phenyl-methyl]-3-methyl-2-aza-bicyclo[2.2.2]oct-7-en-6-yl}-methanol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/ol052436v

Reference yield:

: (1R,2S,6S,7S,9R)-8-{[(E)-(S)-1-Methoxymethyl-2-methyl-propylimino]-phenyl-methyl}-9-methyl-4-oxa-8-aza-tricyclo[5.2.2.0^2,6]undec-10-ene-3,5-dione

: 873545-87-0
[(7,8-bis-benzyloxymethyl-3-methyl-2-aza-bicyclo[2.2.2]oct-5-en-2-yl)-phenyl-methylene]-(1-methoxymethyl-2-methyl-propyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / CH₂Cl₂ / 48 h / 20 °C

2.1: LiAlH₄ / CH₂Cl₂; diethyl ether / 2.5 h / 20 °C

3.1: NaH / dimethylformamide / 0.25 h / 20 °C

3.2: dimethylformamide / 2 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol052436v

Reference yield:

: 873545-83-6
dimethyl 2-[(1-methoxymethyl-2-methyl-propylimino)-phenyl-methyl]-3-methyl-2-azabicyclo[2.2.2]oct-7-ene-5,6-dicarboxylate

: 873545-87-0
[(7,8-bis-benzyloxymethyl-3-methyl-2-aza-bicyclo[2.2.2]oct-5-en-2-yl)-phenyl-methylene]-(1-methoxymethyl-2-methyl-propyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiAlH₄ / CH₂Cl₂; diethyl ether / 2.5 h / 20 °C

2.1: NaH / dimethylformamide / 0.25 h / 20 °C

2.2: dimethylformamide / 2 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol052436v