6-chloro-5-[4-(1-methylpyrrolidin-3-yl)phenyl]-1H-indole-3-carbaldehyde

Base Information

Chemical Name:6-chloro-5-[4-(1-methylpyrrolidin-3-yl)phenyl]-1H-indole-3-carbaldehyde
CAS No.:1467061-20-6
Molecular Formula:C₂₀H₁₉ClN₂O
Molecular Weight:338.837
Hs Code.:

Synonyms:6-chloro-5-[4-(1-methylpyrrolidin-3-yl)phenyl]-1H-indole-3-carbaldehyde

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Chemical Property of 6-chloro-5-[4-(1-methylpyrrolidin-3-yl)phenyl]-1H-indole-3-carbaldehyde

Chemical Property:

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Technology Process of 6-chloro-5-[4-(1-methylpyrrolidin-3-yl)phenyl]-1H-indole-3-carbaldehyde

There total 4 articles about 6-chloro-5-[4-(1-methylpyrrolidin-3-yl)phenyl]-1H-indole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1088410-99-4
3-(4-bromophenyl)-1-methylpyrrolidine

: C₁₄H₁₅BClNO₃

: 1467061-20-6
6-chloro-5-[4-(1-methylpyrrolidin-3-yl)phenyl]-1H-indole-3-carbaldehyde

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 0.5h;

Reference yield:

: 122531-09-3
5-bromo-6-chloro-1H-indole

: 1467061-20-6
6-chloro-5-[4-(1-methylpyrrolidin-3-yl)phenyl]-1H-indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / dimethyl sulfoxide / 1 h / 100 °C

2: N,N-dimethyl(methylene)ammonium chloride / 1,4-dioxane / 0.17 h / 20 °C / Sealed tube

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 0.5 h / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N,N-dimethyl(methylene)ammonium chloride; potassium acetate; potassium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield:

: 1187931-39-0
3-(4-bromophenyl)pyrrolidine hydrochloride

: 1467061-20-6
6-chloro-5-[4-(1-methylpyrrolidin-3-yl)phenyl]-1H-indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; acetic acid / methanol / 0.08 h / 20 °C

1.2: 18 h / 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 0.5 h / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; acetic acid; triethylamine; In 1,4-dioxane; methanol; water;