C₂₇H₃₂N₂O₄

Base Information

• Chemical Name: C₂₇H₃₂N₂O₄
• CAS No.: 1384275-32-4
• Molecular Formula: C₂₇H₃₂N₂O₄
• Molecular Weight: 448.562
• Mol file: 1384275-32-4.mol

Synonyms:C₂₇H₃₂N₂O₄

Chemical Property of C₂₇H₃₂N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₂N₂O₄

There total 8 articles about C₂₇H₃₂N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate → threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate (1384275-34-6) + C27H32N2O4 (1384275-32-4)

Guidance literature:

With CHIRALPAK IA; In hexane; diethylamine; isopropyl alcohol;

Reference yield:

2-(4-methoxyphenyl)quinoline-4-carboxylic acid (4364-02-7) → threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate (1384275-34-6) + C27H32N2O4 (1384275-32-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid / Reflux

2.1: n-butyllithium / diethyl ether / 0.5 h / -78 - -40 °C / Inert atmosphere

2.2: 1.5 h / -70 °C / Inert atmosphere

3.1: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C

4.1: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol; water / 2 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 0 - 20 °C

6.1: CHIRALPAK IA / hexane; isopropyl alcohol; diethylamine

With hydrogenchloride; platinum(IV) oxide; sodium tetrahydroborate; n-butyllithium; sulfuric acid; hydrogen; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; diethylamine; isopropyl alcohol;

Reference yield:

methyl 2-(4-methoxyphenyl)quinoline-4-carboxylate (51842-72-9) → threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate (1384275-34-6) + C27H32N2O4 (1384275-32-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 - -40 °C / Inert atmosphere

1.2: 1.5 h / -70 °C / Inert atmosphere

2.1: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C

3.1: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol; water / 2 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 0 - 20 °C

5.1: CHIRALPAK IA / hexane; isopropyl alcohol; diethylamine

With hydrogenchloride; platinum(IV) oxide; sodium tetrahydroborate; n-butyllithium; hydrogen; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; diethylamine; isopropyl alcohol;

upstream raw materials:

2-(4-methoxyphenyl)quinoline-4-carboxylic acid

methyl 2-(4-methoxyphenyl)quinoline-4-carboxylate

(2-(4-methoxyphenyl)quinolin-4-yl)(pyridin-2-yl)methanone

(2-(4-methoxyphenyl)quinolin-4-yl)(pyridin-2-yl)methanol

Downstream raw materials:

(1R,2R)-(2-(4-methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol hydrochloride