2,4-dichloro-N-(3,5-dimethoxyphenyl)benzamide

Base Information

• Chemical Name: 2,4-dichloro-N-(3,5-dimethoxyphenyl)benzamide
• CAS No.: 305834-39-3
• Molecular Formula: C₁₅H₁₃Cl₂NO₃
• Molecular Weight: 326.179
• DSSTox Substance ID: DTXSID501237128
• Nikkaji Number: J1.399.864G
• Mol file: 305834-39-3.mol

Synonyms:CBMicro_012102;Cambridge id 6233047;2,4-dichloro-N-(3,5-dimethoxyphenyl)benzamide;Oprea1_227870;DTXSID501237128;SMSF0018052;STK205228;AKOS001311792;CB15601;BIM-0012153.P001;AB00104659-01;N-(3,5-Dimethoxyphenyl)-2,4-dichlorobenzamide;SR-01000231068;Benzamide, 2,4-dichloro-N-(3,5-dimethoxyphenyl)-;SR-01000231068-1;Z30885900;305834-39-3

Chemical Property of 2,4-dichloro-N-(3,5-dimethoxyphenyl)benzamide

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 325.0272487
• Heavy Atom Count: 21
• Complexity: 344

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)NC(=O)C2=C(C=C(C=C2)Cl)Cl)OC

Technology Process of 2,4-dichloro-N-(3,5-dimethoxyphenyl)benzamide

There total 1 articles about 2,4-dichloro-N-(3,5-dimethoxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichlorobenzoyl chloride (89-75-8) + 3.5-dimethoxyaniline (10272-07-8) → 2,4-dichloro-N-(3,5-dimethoxy-phenyl)-benzamide (305834-39-3)

Guidance literature:

With triethylamine;

DOI:10.1016/S0040-4039(00)01226-0

Reference yield: 28.0%

Methoxyacetyl chloride (38870-89-2) + 2,4-dichloro-N-(3,5-dimethoxy-phenyl)-benzamide (305834-39-3) → 2,4-dichloro-N-(3,5-dimethoxy-2-methoxyacetyl-phenyl)-benzamide (305834-45-1)

Guidance literature:

With tin(IV) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 4h;

DOI:10.1016/S0040-4039(00)01226-0

Reference yield:

2,4-dichloro-N-(3,5-dimethoxy-phenyl)-benzamide (305834-39-3) → 2-(2,4-dichloro-phenyl)-3,5,7-trimethoxy-1H-quinolin-4-one

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / SnCl₄ / 1,2-dichloro-ethane / 4 h / 20 °C

2: 79 percent / tBuOK / 2-methyl-propan-2-ol / 24 h / 80 °C

With potassium tert-butylate; tin(IV) chloride; In 1,2-dichloro-ethane; tert-butyl alcohol; 1: Substitution / 2: Cyclization;

DOI:10.1016/S0040-4039(00)01226-0

upstream raw materials:

2,4-dichlorobenzoyl chloride

3.5-dimethoxyaniline

Downstream raw materials:

2,4-dichloro-N-(3,5-dimethoxy-2-methoxyacetyl-phenyl)-benzamide