Technology Process of (E)-ethyl 4-((1s,4s)-4-azidocyclohexyl)-2-methylbut-2-enoate
There total 5 articles about (E)-ethyl 4-((1s,4s)-4-azidocyclohexyl)-2-methylbut-2-enoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: borane-THF / tetrahydrofuran / 4 h / 0 - 20 °C
2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Cooling with ice
3.1: potassium carbonate; copper(ll) sulfate pentahydrate; imidazole-1-sulfonyl azide hydrochloride / methanol / 20 °C / Cooling with ice
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
4.2: 1 h / 20 °C
5.1: 0.17 h / 20 °C / Cooling with ice
With
imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; borane-THF; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane;
4.1: |Swern Oxidation / 4.2: |Swern Oxidation;
DOI:10.1021/jm401370h
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
1.2: 1 h / 20 °C
2.1: 0.17 h / 20 °C / Cooling with ice
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
1.1: |Swern Oxidation / 1.2: |Swern Oxidation;
DOI:10.1021/jm401370h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate; copper(ll) sulfate pentahydrate; imidazole-1-sulfonyl azide hydrochloride / methanol / 20 °C / Cooling with ice
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
2.2: 1 h / 20 °C
3.1: 0.17 h / 20 °C / Cooling with ice
With
imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide;
In
methanol; dichloromethane;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jm401370h
