bis(1,1-dimethylethyl) (7-cyano-3-(1-[(2,5-difluorophenyl)acet yI]-2,3-dihydro-1H-indol-5-yl)furo[3,2-c]pyridin-4-yI)imidodicarbonate

Base Information

Chemical Name:bis(1,1-dimethylethyl) (7-cyano-3-(1-[(2,5-difluorophenyl)acet yI]-2,3-dihydro-1H-indol-5-yl)furo[3,2-c]pyridin-4-yI)imidodicarbonate
CAS No.:1337533-30-8
Molecular Formula:C₃₄H₃₂F₂N₄O₆
Molecular Weight:630.648
Hs Code.:

Synonyms:bis(1,1-dimethylethyl) (7-cyano-3-(1-[(2,5-difluorophenyl)acet yI]-2,3-dihydro-1H-indol-5-yl)furo[3,2-c]pyridin-4-yI)imidodicarbonate

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Chemical Property of bis(1,1-dimethylethyl) (7-cyano-3-(1-[(2,5-difluorophenyl)acet yI]-2,3-dihydro-1H-indol-5-yl)furo[3,2-c]pyridin-4-yI)imidodicarbonate

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Technology Process of bis(1,1-dimethylethyl) (7-cyano-3-(1-[(2,5-difluorophenyl)acet yI]-2,3-dihydro-1H-indol-5-yl)furo[3,2-c]pyridin-4-yI)imidodicarbonate

There total 3 articles about bis(1,1-dimethylethyl) (7-cyano-3-(1-[(2,5-difluorophenyl)acet yI]-2,3-dihydro-1H-indol-5-yl)furo[3,2-c]pyridin-4-yI)imidodicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 748101-41-9
zinc cyanide

: 1337533-20-6
bis(1,1-dimethylethyl) (3-(1-[(2,5-difluorophenyI)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-iodofuro[3,2-c]pyridin-4-yI)imidodicarbonate

: 1337533-30-8
bis(1,1-dimethylethyl) (7-cyano-3-(1-[(2,5-difluorophenyl)acet yI]-2,3-dihydro-1H-indol-5-yl)furo[3,2-c]pyridin-4-yI)imidodicarbonate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1337531-46-0
3-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}furo[3,2-c]pyridin-4-amine

: 1337533-30-8
bis(1,1-dimethylethyl) (7-cyano-3-(1-[(2,5-difluorophenyl)acet yI]-2,3-dihydro-1H-indol-5-yl)furo[3,2-c]pyridin-4-yI)imidodicarbonate

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 18 h / -40 - 20 °C

2: triethylamine / dmap / dichloromethane / 17 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With N-iodo-succinimide; triethylamine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1337532-96-3
3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-iodofuro[3,2-c]pyridin-4-amine

: 1337533-30-8
bis(1,1-dimethylethyl) (7-cyano-3-(1-[(2,5-difluorophenyl)acet yI]-2,3-dihydro-1H-indol-5-yl)furo[3,2-c]pyridin-4-yI)imidodicarbonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dmap / dichloromethane / 17 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With triethylamine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;