(tetrahydro-4-methyl-5-oxofuran-2-yl)methyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: (tetrahydro-4-methyl-5-oxofuran-2-yl)methyl 4-methylbenzenesulfonate
• CAS No.: 107971-37-9
• Molecular Formula: C₁₃H₁₆O₅S
• Molecular Weight: 284.333
• Mol file: 107971-37-9.mol

Synonyms:(tetrahydro-4-methyl-5-oxofuran-2-yl)methyl 4-methylbenzenesulfonate

Chemical Property of (tetrahydro-4-methyl-5-oxofuran-2-yl)methyl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (tetrahydro-4-methyl-5-oxofuran-2-yl)methyl 4-methylbenzenesulfonate

There total 9 articles about (tetrahydro-4-methyl-5-oxofuran-2-yl)methyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(+-)-2-methyl-pent-4-enoic acid (1575-74-2) + toluene-4-sulfonic acid (104-15-4) → (tetrahydro-4-methyl-5-oxofuran-2-yl)methyl 4-methylbenzenesulfonate (107971-37-9)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In tetrahydrofuran; for 0.0333333h; ultrasound irradiation;

DOI:10.1080/15533174.2011.591326

Reference yield: 82.0%

(3R,5S)-(+)-trans-5-hydroxymethyl-3-methyl-4,5-dihydro-2(3H)-furanone (53078-05-0) + p-toluenesulfonyl chloride (98-59-9) → ((2S,4R)-4-methyl-5-oxotetrahydrofuran-2-yl)methyl-4-methyl benzenesulfonate (107971-37-9)

Guidance literature:

(3R,5S)-(+)-trans-5-hydroxymethyl-3-methyl-4,5-dihydro-2(3H)-furanone; With triethylamine; In dichloromethane; at 0 ℃; for 0.0833333h;

p-toluenesulfonyl chloride; In dichloromethane; at 0 - 23 ℃; for 5h;

DOI:10.1016/j.tetlet.2021.152906

Reference yield: 65.0%

(+-)-2-methyl-pent-4-enoic acid (1575-74-2) + [hydroxy(tosyloxy)iodo]benzene (27126-76-7) → (tetrahydro-4-methyl-5-oxofuran-2-yl)methyl 4-methylbenzenesulfonate (107971-37-9)

Guidance literature:

In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(00)85002-9

upstream raw materials:

(+-)-2-methyl-pent-4-enoic acid

[hydroxy(tosyloxy)iodo]benzene

toluene-4-sulfonic acid

(S)-5-tosyloxypentan-4-olide