(R)-S-ethyl 3-(4'-chlorophenyl)-3[(2'-hydroxyphenyl)amino]propane thioate

Base Information

Chemical Name:(R)-S-ethyl 3-(4'-chlorophenyl)-3[(2'-hydroxyphenyl)amino]propane thioate
CAS No.:192565-61-0
Molecular Formula:C₁₇H₁₈ClNO₂S
Molecular Weight:335.854
Hs Code.:

Synonyms:(R)-S-ethyl 3-(4'-chlorophenyl)-3[(2'-hydroxyphenyl)amino]propane thioate

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Chemical Property of (R)-S-ethyl 3-(4'-chlorophenyl)-3[(2'-hydroxyphenyl)amino]propane thioate

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Technology Process of (R)-S-ethyl 3-(4'-chlorophenyl)-3[(2'-hydroxyphenyl)amino]propane thioate

There total 3 articles about (R)-S-ethyl 3-(4'-chlorophenyl)-3[(2'-hydroxyphenyl)amino]propane thioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117909-29-2
(E)-N-(4-chlorobenzylidene)-2-hydroxyaniline

: 63584-41-8
1-ethylthio-1-(trimethylsiloxy)ethene

: 192565-61-0
(R)-S-ethyl 3-(4'-chlorophenyl)-3[(2'-hydroxyphenyl)amino]propane thioate

: S-ethyl (R)-3-(4-chlorophenyl)-3-[(2-hydroxyphenyl)amino]propanethioate

Guidance literature:: With (R)-3-(2-hydroxy-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; 1-methyl-1H-imidazole; 3 A molecular sieve; Nb(OMe)5; In dichloromethane; toluene; at -20 ℃; for 48h; Title compound not separated from byproducts;
DOI:10.1002/anie.200462204

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 192565-61-0
(R)-S-ethyl 3-(4'-chlorophenyl)-3[(2'-hydroxyphenyl)amino]propane thioate

Guidance literature:: Multi-step reaction with 2 steps

1: molecular sieves 4 Angstroem / CH₂Cl₂; dimethylformamide / 20 °C

2: (R)-3-(2-OH-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; N-methylimidazole; molecular sieves 3 Angstroem / Nb(OMe)5 / toluene; CH₂Cl₂ / 48 h / -20 °C

With (R)-3-(2-hydroxy-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; 1-methyl-1H-imidazole; 3 A molecular sieve; 4 A molecular sieve; Nb(OMe)5; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.200462204

Reference yield:

: 95-55-6
2-amino-phenol

: 192565-61-0
(R)-S-ethyl 3-(4'-chlorophenyl)-3[(2'-hydroxyphenyl)amino]propane thioate

Guidance literature:: Multi-step reaction with 2 steps

1: molecular sieves 4 Angstroem / CH₂Cl₂; dimethylformamide / 20 °C

2: (R)-3-(2-OH-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; N-methylimidazole; molecular sieves 3 Angstroem / Nb(OMe)5 / toluene; CH₂Cl₂ / 48 h / -20 °C

With (R)-3-(2-hydroxy-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; 1-methyl-1H-imidazole; 3 A molecular sieve; 4 A molecular sieve; Nb(OMe)5; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.200462204