1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine

Base Information

Chemical Name:1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine
CAS No.:1408088-34-5
Molecular Formula:C₁₇H₂₆BFN₂O₂
Molecular Weight:320.215
Hs Code.:

Synonyms:1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine

Suppliers and Price of 1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine

There total 3 articles about 1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1352207-52-3
1-(4-bromo-2-fluorophenyl)-4-methylpiperazine

: 73183-34-3
bis(pinacol)diborane

: 1408088-34-5
1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; at 20 - 90 ℃; for 2h; Inert atmosphere;

Reference yield: 24.0%

: 1408088-34-5
1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine

Guidance literature:

Reference yield:

: 221198-99-8
1-(2-fluoro-4-aminophenyl)-4-methylpiperazine

: 1408088-34-5
1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; hydrogen bromide; sodium nitrite / water / 0.5 h / Cooling with ice

1.2: 2 h

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 2 h / 20 - 90 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen bromide; potassium acetate; acetic acid; sodium nitrite; In water;