(1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester
CAS No.:869959-34-2
Molecular Formula:C₃₀H₄₁BrN₄O₅
Molecular Weight:617.583
Hs Code.:

Synonyms:(1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

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Chemical Property of (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

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Technology Process of (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

There total 1 articles about (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (S)-2-Amino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide; compound with trifluoro-acetic acid

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 869959-34-2
(1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jo051412z

Reference yield:

: 869959-34-2
(1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

: 11-benzyl-8-isopropyl-5-methyl-3,6,9,12-tetraaza-bicyclo[16.3.1]docosa-1⁽²²⁾,18,20-trien-16-yne-4,7,10,13-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 2 h / 20 °C

2: 76 percent / Et₃N; HOBt; EDC / CH₂Cl₂ / 15 h / 20 °C

3: 12 percent / (o-tolyl)3P; N-ethyldiisopropylamine / Pd(OAc)2 / acetonitrile / 15 h / 110 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium diacetate; In dichloromethane; acetonitrile; 3: Sonogashira coupling;
DOI:10.1021/jo051412z

Reference yield:

: 869959-34-2
(1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

: deca-4,6-diynedioic acid bis-[(1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-amide]

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 2 h / 20 °C

2: 76 percent / Et₃N; HOBt; EDC / CH₂Cl₂ / 15 h / 20 °C

3: 90 percent / Et₃N / (Ph₃P)2PdCl₂; CuI / acetonitrile; dimethylformamide / 15 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo051412z