pent-4-ynoic acid (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-phenyl-ethyl)-amide

Base Information

Chemical Name:pent-4-ynoic acid (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-phenyl-ethyl)-amide
CAS No.:869959-35-3
Molecular Formula:C₃₀H₃₇BrN₄O₄
Molecular Weight:597.552
Hs Code.:

Synonyms:pent-4-ynoic acid (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-phenyl-ethyl)-amide

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Chemical Property of pent-4-ynoic acid (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-phenyl-ethyl)-amide

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Technology Process of pent-4-ynoic acid (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-phenyl-ethyl)-amide

There total 2 articles about pent-4-ynoic acid (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide; compound with trifluoro-acetic acid

: 6089-09-4
4-pentynoic acid

: 869959-35-3
pent-4-ynoic acid (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-phenyl-ethyl)-amide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jo051412z

Reference yield:

: 869959-34-2
(1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

: 869959-35-3
pent-4-ynoic acid (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 2 h / 20 °C

2: 76 percent / Et₃N; HOBt; EDC / CH₂Cl₂ / 15 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane;
DOI:10.1021/jo051412z

Reference yield: 90.0%

: 869959-35-3
pent-4-ynoic acid (1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-phenyl-ethyl)-amide

: deca-4,6-diynedioic acid bis-[(1-{1-[1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-amide]

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 15h;
DOI:10.1021/jo051412z