Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate

Base Information

Chemical Name:Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate
CAS No.:1334536-92-3
Molecular Formula:C₃₁H₃₁F₂N₃O₄
Molecular Weight:547.602
Hs Code.:

Synonyms:Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate

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Chemical Property of Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate

Chemical Property:

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Technology Process of Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate

There total 5 articles about Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 1219624-96-0
2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid

: 1334536-92-3
Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 386-99-2
ethyl 2,2-bis(4-fluorophenyl)acetate

: 1334536-92-3
Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium ethanolate / 1,4-dioxane / 0.5 h / 40 - 45 °C

1.2: 1 h / 60 - 70 °C

2.1: hydrogen; ammonia / methanol / 24 h / 20 °C / 1551.49 Torr

3.1: potassium tert-butylate / tetrahydrofuran / 80 °C / Inert atmosphere

4.1: water; lithium hydroxide / ethanol / 2 h / 80 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; potassium tert-butylate; ammonia; water; hydrogen; sodium ethanolate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane;

Reference yield:

: 1219624-93-7
ethyl 4-cyano-2,2-bis(4-fluorophenyl)butanoate

: 1334536-92-3
Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; ammonia / methanol / 24 h / 20 °C / 1551.49 Torr

2: potassium tert-butylate / tetrahydrofuran / 80 °C / Inert atmosphere

3: water; lithium hydroxide / ethanol / 2 h / 80 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; potassium tert-butylate; ammonia; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;