386-99-2

Upstream product

• 475-26-3 1,1'-(2,2,2-trichloroethylidene)bis(p-fluorobenzene) 
• 141-78-6 ethyl acetate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 64-17-5 ethanol 
• 579-39-5 1,2-bis(4-fluorophenyl)ethane-1,2-dione 
• 53458-16-5 1,2-bis(4-fluorophenyl)-2-hydroxyethan-1-one 
• 122-51-0 orthoformic acid triethyl ester 
• 733-83-5 2,2,2-trifluoro-1,1-bis(4-fluorophenyl)ethanol 
• 789-03-7 1,1,1-trifluoro-2,2-bis(p-fluorophenyl)ethane 
• 361-63-7 2,2-bis(4-fluorophenyl)acetic acid 

Downstream Products

• 1334536-81-0 3,3-Bis(4-fluorophenyl)-1-(2-oxo-2-piperazin-1-ylethyl)piperidin-2-one 
• 1334536-92-3 Benzyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetyl)piperazine-1-carboxylate 
• 1219625-68-9 1-(2-(7-Benzyl-2,7-diazaspiro[3.5]nonan-2-yl)-2-oxoethyl)-3,3-bis(4-fluorophenyl)pyrrolidin-2-one 
• 1219624-96-0 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid 
• 1219624-95-9 ethyl 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetate 
• 1219624-94-8 3,3-bis(4-fluorophenyl)piperidin-2-one 
• 1219624-45-9 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid 
• 1219624-44-8 ethyl 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetate 
• 1219624-43-7 3,3-bis(4-fluorophenyl)pyrrolidin-2-one 
• 1219624-42-6 ethyl 3-cyano-2,2-bis(4-fluorophenyl)propanoate 
• 1219624-93-7 ethyl 4-cyano-2,2-bis(4-fluorophenyl)butanoate 

Relevant academic research and scientific papers

Photoredox Catalytic Phosphite-Mediated Deoxygenation of α-Diketones Enables Wolff Rearrangement and Staudinger Synthesis of β-Lactams

A novel visible-light-driven catalytic activation of C=O bonds by exploiting the photoredox chemistry of 1,3,2-dioxaphospholes, readily accessible from α-diketones and trialkyl phosphites, is reported. This mild and environmentally friendly strategy provides an unprecedented and efficient access to the Wolff rearrangement reaction which traditionally entails α-diazoketones as precursors. The resulting ketenes could be precisely trapped by alcohols/thiols to give α-aryl (thio)acetates and by imines to afford the valuable β-lactams in up to 99 % yields.

Diaryl acetate compound and preparation method thereof

The invention provides a diaryl acetate compound and a preparation method, and the preparation method comprises the following steps: (1) adding a diary 1, 2-diketone compound, an alcohol compound, trialkyl phosphite and a photocatalyst into a reaction vessel, adding a solvent, and dissolving to obtain a reaction solution; (2) irradiating an reaction liquid by using a light source and stirring until the reaction is complete; and (3) after the reaction is finished, recovering the solvent under reduced pressure and purifying by column chromatography to obtain the diaryl acetate compound. Startingfrom easily available diaryl 1, 2-diketone, the method has the advantages of mild and green reaction conditions, no need of precious transition metal catalysis, economical performance, environmentalprotection, and high practicality.

Synthesis of chiral α-diarylacetic esters by stereospecific 1,2-aryl migration promoted by in situ generated acetals from benzoins

A simple protocol for the synthesis of α-diarylacetic esters from benzoins is described. In situ generated acetal assists rapid 1,2-aryl migration in a stereospecific manner, paving the way to make enantioenriched α-diarylacetic esters from easily accessi

Palladium/copper-catalyzed Di-α-arylation of acetic acid esters

A bimetallic palladium/copper catalyst system was found to effectively promote the diarylation of alkyl acetates with aryl halides under unprecedentedly mild conditions. The phenanthroline-copper-phosphine catalyst stabilizes the enolate intermediate to the extent that the deprotonation of esters can be achieved even with the mild base potassium phosphate. The palladium tri-tert-butylphosphine co-catalyst mediates the coupling of the resulting copper enolate with a wide variety of aryl halides with selective formation of the corresponding diarylacetic acid esters. Copyright