N⁴-cyclopentyl-N²-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride

Base Information

• Chemical Name: N⁴-cyclopentyl-N²-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride
• CAS No.: 1414781-18-2
• Molecular Formula: C₁₉H₂₄N₆O₃*ClH
• Molecular Weight: 420.899

Synonyms:N⁴-cyclopentyl-N²-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride

Chemical Property of N⁴-cyclopentyl-N²-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride

Chemical Property:

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Technology Process of N⁴-cyclopentyl-N²-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride

There total 3 articles about N⁴-cyclopentyl-N²-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-morpholino-4-nitrobenzene (10389-51-2) → N4-cyclopentyl-N2-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride (1414781-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 9 h / 20 °C / 760.05 Torr

2: butan-1-ol / 5 h / 90 °C

With palladium 10% on activated carbon; hydrogen; In ethanol; butan-1-ol;

DOI:10.1021/jm301365e

Reference yield:

Cyclopentamine (1003-03-8) → N4-cyclopentyl-N2-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride (1414781-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -60 °C

2: butan-1-ol / 5 h / 90 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; butan-1-ol;

DOI:10.1021/jm301365e

Reference yield:

2-chloro-N-cyclopentyl-5-nitropyrimidin-4-amine (330550-92-0) + 4-morpholino-4-yl-phenylamine (2524-67-6,86759-37-7) → N4-cyclopentyl-N2-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride (1414781-18-2)

Guidance literature:

In butan-1-ol; at 90 ℃; for 5h;

DOI:10.1021/jm301365e

upstream raw materials:

2-chloro-N-cyclopentyl-5-nitropyrimidin-4-amine

4-morpholino-4-yl-phenylamine

Cyclopentamine

1-morpholino-4-nitrobenzene

Downstream raw materials:

C₂₆H₂₉N₇O

5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

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