1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate

Base Information

Chemical Name:1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate
CAS No.:1354691-99-8
Molecular Formula:C₉H₉NO₃*C₂₁H₂₅F₃N₆O₂
Molecular Weight:629.639
Hs Code.:

Synonyms:1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate

Suppliers and Price of 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate

There total 10 articles about 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 1354690-24-6
1-[(3S)-3-({5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]pyrido[4,3-d]pyrimidin-4-yl}amino)pyrrolidin-1-yl]propan-1-one

: 1354691-99-8
1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate

Guidance literature:: In water; acetonitrile; at 20 - 70 ℃; for 16.5h;

Reference yield:

: 121643-44-5
2-methoxy-3-(trifluoromethyl)pyridine

: 1354691-99-8
1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / trifluoroacetic acid / 18 h / 20 °C / Inert atmosphere

2.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine / tert-butyl alcohol / 4 h / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: 1.33 h / 20 °C

4.1: water; acetonitrile / 70 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; trifluoroacetic acid; sodium t-butanolate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; In dichloromethane; water; acetonitrile; trifluoroacetic acid; tert-butyl alcohol;

Reference yield:

: 914612-23-0
6-benzyl-4-chloro-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidine

: 1354691-99-8
1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 120 °C

2.1: 10 wt% Pd(OH)2 on carbon; triethylammonium formate / methanol / 1 h / Reflux; Inert atmosphere

3.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine / tert-butyl alcohol / 4 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: 1.33 h / 20 °C

5.1: water; acetonitrile / 70 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; triethylammonium formate; potassium carbonate; trifluoroacetic acid; sodium t-butanolate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;