Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-

Base Information

Chemical Name:Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-
CAS No.:868612-83-3
Molecular Formula:C₂₅H₂₀N₆O
Molecular Weight:420.473
Hs Code.:
UNII:KW4O83PQ97
ChEMBL ID:CHEMBL492634
Pharos Ligand ID:SZ1V4YJX33N3
Wikidata:Q27282469

Synonyms:3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide;IN 1130;IN-1130;IN1130

Suppliers and Price of Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
IN1130
2.5mg
$ 250.00

Tocris
IN1130 ≥98%(HPLC)
5
$ 116.00

ChemScene
IN-1130
100mg
$ 950.00

ChemScene
IN-1130
50mg
$ 550.00

ChemScene
IN-1130
25mg
$ 350.00

ChemScene
IN-1130
10mg
$ 170.00

ChemScene
IN-1130
5mg
$ 100.00

Total 3 raw suppliers

Chemical Property of Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:420.16985928
Heavy Atom Count:32
Complexity:646

Purity/Quality:

97% ^*data from raw suppliers

IN1130 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=NC(=CC=C1)C2=C(N=C(N2)CC3=CC(=CC=C3)C(=O)N)C4=CC5=NC=CN=C5C=C4
Uses IN 1130 is a novel transforming growth factor-?β type I receptor kinase (ALK5) inhibtior. In one study, it showed that IN-1130 was effective in prevention and treatment of renal fibrosis in rat unilateral ureteral obstruction model.

Technology Process of Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-

There total 5 articles about Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1⁽³⁾H-imidazol-2-yl)methyl)benzonitrile

: 868612-83-3
IN-1130

Guidance literature:: With sodium hydroxide; ethanol; water; dihydrogen peroxide; at 40 ℃; for 0.5h;

Reference yield:

: C₂₅H₂₀N₆O₂

: 868612-83-3
IN-1130

Guidance literature:: With triethyl phosphite; In N,N-dimethyl-formamide; at 110 ℃; for 72h;
DOI:10.1080/14756366.2020.1734799

Reference yield:

: 356560-77-5
1-(6-methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethane-1,2-dione 1-oxime

: 868612-83-3
IN-1130

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / methanol; tert-butyl methyl ether / 20 °C / Inert atmosphere

2: dihydrogen peroxide; sodium hydroxide / ethanol; dimethyl sulfoxide / 55 °C

3: triethyl phosphite / N,N-dimethyl-formamide / 72 h / 110 °C

With ammonium acetate; dihydrogen peroxide; sodium hydroxide; triethyl phosphite; In methanol; ethanol; tert-butyl methyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1080/14756366.2020.1734799