2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone

Base Information

Chemical Name:2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone
CAS No.:356560-90-2
Molecular Formula:C₁₆H₁₃N₃O
Molecular Weight:263.299
Hs Code.:
Mol file:356560-90-2.mol

Synonyms:2-(6-methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone;6-[2-(6-Methylpyridin-2-yl)-acetyl]quinoxaline;

Suppliers and Price of 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 7 raw suppliers

Chemical Property of 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone

Chemical Property:

Melting Point:139-140 °C
Boiling Point:443.2±40.0 °C(Predicted)
PKA:4.62±0.12(Predicted)
PSA：55.74000
Density:1.243±0.06 g/cm3(Predicted)
LogP:2.75860

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone

There total 1 articles about 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 108-48-5
2,6-dimethylpyridine

: 258503-93-4
quinoxaline-6-carbonyl chloride

: 356560-90-2
2-(6-methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone

Guidance literature:: 2,6-dimethylpyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -60 ℃; for 0.5h;

With diethylaluminium chloride; In tetrahydrofuran; hexane; at -60 - 20 ℃;

quinoxaline-6-carbonyl chloride; In tetrahydrofuran; hexane; at -60 ℃; for 0.333333h; Further stages.;
DOI:10.1021/jm070129k DOI:10.1016/j.bmcl.2008.01.084

Reference yield: 86.0%

: 356560-90-2
2-(6-methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone

: 364050-21-5
1-(6-methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethane-1,2-dione

Guidance literature:: With aq. HBr; In dimethyl sulfoxide;

Reference yield:

: 356560-90-2
2-(6-methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone

: C₂₅H₁₉N₇

Guidance literature:: Multi-step reaction with 4 steps

1.1: 66 percent / DMSO; aq. HBr / 2 h / 60 - 70 °C

2.1: 83 percent / various solvent(s); methanol; H₂O / 3 h / 20 °C

3.1: 94 percent / aq. HCl / 3 h / 70 °C

4.1: AcOH / 1,2-dichloro-ethane / 1 h / 20 °C

4.2: 48 percent / sodium triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C

With hydrogenchloride; hydrogen bromide; acetic acid; dimethyl sulfoxide; In methanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm070129k