1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-(3-ethylureido)pyridin-4-yl)methyl)naphthalen-1-yl)urea

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Chemical Name:1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-(3-ethylureido)pyridin-4-yl)methyl)naphthalen-1-yl)urea
CAS No.:1338814-71-3
Molecular Formula:C₃₄H₃₇N₇O₂
Molecular Weight:575.713
Hs Code.:

Synonyms:1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-(3-ethylureido)pyridin-4-yl)methyl)naphthalen-1-yl)urea

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Chemical Property of 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-(3-ethylureido)pyridin-4-yl)methyl)naphthalen-1-yl)urea

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Technology Process of 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-(3-ethylureido)pyridin-4-yl)methyl)naphthalen-1-yl)urea

There total 6 articles about 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-(3-ethylureido)pyridin-4-yl)methyl)naphthalen-1-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1338815-65-8
1-(4-((2-aminopyridin-4-yl)methyl)naphthalen-1-yl)-3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)urea

: 109-90-0
ethyl isocyanate

: 1338814-71-3
1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-(3-ethylureido)pyridin-4-yl)methyl)naphthalen-1-yl)urea

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 43.3333h; Inert atmosphere;

Reference yield:

: 304873-65-2
2-[N,N-mono-(tert-butoxycarbonyl)amino]-pyridyl-4-aldehyde

: 1338814-71-3
1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-(3-ethylureido)pyridin-4-yl)methyl)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1.75 h / -78 °C / Inert atmosphere

1.2: 19 h / -78 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / 2.83 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 4.33 h / 0 - 20 °C / Inert atmosphere

5.1: dichloromethane / 2.08 h / Inert atmosphere

5.2: 21.5 h / 0 - 20 °C / Inert atmosphere

6.1: dichloromethane / 43.33 h / 0 - 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; n-butyllithium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexanes; dichloromethane;

Reference yield:

: 168169-11-7
4-bromo-N-(tert-butoxycarbonyl)-1-naphthylamine

: 1338814-71-3
1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-(3-ethylureido)pyridin-4-yl)methyl)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1.75 h / -78 °C / Inert atmosphere

1.2: 19 h / -78 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / 2.83 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 4.33 h / 0 - 20 °C / Inert atmosphere

5.1: dichloromethane / 2.08 h / Inert atmosphere

5.2: 21.5 h / 0 - 20 °C / Inert atmosphere

6.1: dichloromethane / 43.33 h / 0 - 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; n-butyllithium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexanes; dichloromethane;