methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate

Base Information

• Chemical Name: methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate
• CAS No.: 716360-90-6
• Molecular Formula: C₁₀H₁₀F₃NO₄S
• Molecular Weight: 297.255
• Mol file: 716360-90-6.mol

Synonyms:methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate

Chemical Property of methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate

Chemical Property:

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Technology Process of methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate

There total 1 articles about methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trifluoromethylsulfonic anhydride (358-23-6) + methyl 4-(aminomethyl)benzoate (18469-52-8) → methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate (716360-90-6)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

DOI:10.1007/s00775-010-0716-0

Reference yield: 76.0%

methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate (716360-90-6) → C9H9F3N2O4S (1259370-88-1)

Guidance literature:

With water; hydroxylamine sulfate; sodium hydroxide; at 20 ℃; for 0.0833333h;

methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate; With sodium sulfite; at 45 ℃; for 16h;

DOI:10.1007/s00775-010-0716-0

Reference yield: 75.0%

dimethyl diazomalonate (6773-29-1) + methyl 4-[(trifluoromethylsulfonamido)methyl]benzoate (716360-90-6) → tetramethyl 2,2'-(5-(methoxycarbonyl)-2-((trifluoromethylsulfonamido)methyl)-1,3-phenylene)dimalonate

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; In methanol; at 60 ℃; for 20h;

DOI:10.1002/bkcs.10574

upstream raw materials:

trifluoromethylsulfonic anhydride

methyl 4-(aminomethyl)benzoate

Downstream raw materials:

C₉H₉F₃N₂O₄S