Methyl 4-(aminomethyl)benzoate

Base Information

• Chemical Name: Methyl 4-(aminomethyl)benzoate
• CAS No.: 18469-52-8
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2922499990
• Mol file: 18469-52-8.mol

Synonyms:p-Toluicacid, a-amino-, methyl ester (6CI,8CI);Methyl p-(aminomethyl)benzoate;Methyl a-amino-p-toluate;p-(Methoxycarbonyl)benzylamine;Methyl4-(aminomethyl)benzoate;4-Methoxycarbonylbenzylamine;4-(Aminomethyl)benzoic acid, methyl ester;

Chemical Property of Methyl 4-(aminomethyl)benzoate

Chemical Property:

• Melting Point: 243 °C (dec.)(lit.)
• Boiling Point: 278.699 °C at 760 mmHg
• PKA: 8.67±0.10(Predicted)
• Flash Point: 138.116 °C
• PSA: 52.32000
• Density: 1.121 g/cm³
• LogP: 2.43420
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

methyl4-(aminomethyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-(aminomethyl)benzoate

There total 29 articles about Methyl 4-(aminomethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 4-(azidomethyl)benzoate (94341-53-4) → methyl 4-(aminomethyl)benzoate (18469-52-8)

Guidance literature:

With sodium hydrogen telluride; In diethyl ether; ethanol; for 0.25h; Ambient temperature;

DOI:10.1246/cl.1984.1733

Reference yield: 96.0%

4-cyanobenzoic acid methyl ester (1129-35-7) → methyl 4-(aminomethyl)benzoate (18469-52-8)

Guidance literature:

With hydrogen; silica gel; nickel; In methanol; ammonia; at 120 ℃; for 2h; under 7600 Torr;

DOI:10.1055/s-2001-17481

Reference yield: 95.0%

methanol (67-56-1) + p-aminomethylbenzoic acid (56-91-7) → methyl 4-(aminomethyl)benzoate (18469-52-8)

Guidance literature:

With hydrogenchloride; In water; at 85 ℃; for 16h;

DOI:10.1002/cmdc.202000438

upstream raw materials:

4-cyanobenzoic acid methyl ester

methyl 4-(azidomethyl)benzoate

methanol

p-aminomethylbenzoic acid

Downstream raw materials:

4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester

methyl 4-<<(4-fluoro-2-nitrophenyl)amino>methyl>benzoate

4-{[(S)-2-tert-Butoxycarbonylamino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid methyl ester

N-(4-methoxycarbonylbenzyl)-4-methylbenzenesulfonamide