(1'S,3S,4R)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone

Base Information

• Chemical Name: (1'S,3S,4R)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone
• CAS No.: 112245-38-2
• Molecular Formula: C₂₁H₂₃NO₅S
• Molecular Weight: 401.483
• Mol file: 112245-38-2.mol

Synonyms:(1'S,3S,4R)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone

Chemical Property of (1'S,3S,4R)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'S,3S,4R)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone

There total 1 articles about (1'S,3S,4R)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + (1'S,3S)-3-(1'-hydroxyethyl)-1-(4'-methoxyphenyl)-4-(2'-phenylethenyl)-2-azetidinone (205525-21-9) → (1'S,3S,4R)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone (112245-38-2) + (1'S,3S,4S)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone (112245-39-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 4h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00238a041

Reference yield: 93.0%

(1'S,3S,4RS)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone (100009-44-7,106399-91-1,112245-38-2,112245-39-3) → 3-Eth-(Z)-ylidene-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one (112113-97-0) + (R)-3-((S)-1-Iodo-ethyl)-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one

Guidance literature:

With sodium iodide; In acetone; for 12h; Heating;

DOI:10.1021/jo00238a041

Reference yield: 83.0%

(1'S,3S,4R)-1-(4-methoxyphenyl)-3-<1'-<(methylsulfonyl)oxy>ethyl>-4-(2'-phenylethenyl)-2-azetidinone (112245-38-2) → (R)-3-Eth-(Z)-ylidene-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one

Guidance literature:

With sodium hydrogencarbonate; In methanol; at 65 ℃; for 2h;

DOI:10.1021/ja00238a023

upstream raw materials:

methanesulfonyl chloride

(1'S,3S)-3-(1'-hydroxyethyl)-1-(4'-methoxyphenyl)-4-(2'-phenylethenyl)-2-azetidinone

Downstream raw materials:

(3S,4R)-1-p-methoxyphenyl-3-<(R)-1-nitroxyethyl>-4-styrylazetidin-2-one

(3S,4S)-1-p-methoxyphenyl-3-<(R)-1-nitroxyethyl>-4-styrylazetidin-2-one

3-Eth-(Z)-ylidene-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one

(3R)-4-Acetoxy-3-ethyl-2-azetidinone