4'-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}-1,1'-biphenyl-4-carbonitrile

Base Information

Chemical Name:4'-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}-1,1'-biphenyl-4-carbonitrile
CAS No.:1380049-02-4
Molecular Formula:C₁₉H₁₇NO₂
Molecular Weight:291.349
Hs Code.:

Synonyms:4'-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}-1,1'-biphenyl-4-carbonitrile

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Chemical Property of 4'-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}-1,1'-biphenyl-4-carbonitrile

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Technology Process of 4'-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}-1,1'-biphenyl-4-carbonitrile

There total 4 articles about 4'-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}-1,1'-biphenyl-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 120-92-3
cyclopentanone

: 50670-55-8
4-(4-cyanophenyl)-benzaldehyde

: 1380049-02-4
4'-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}-1,1'-biphenyl-4-carbonitrile

Guidance literature:: With (2S,4R)-4-(2,2-diphenylacetoxy)pyrrolidine-2-carboxylic acid; In water; at 20 ℃; for 22h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/ejoc.201200092

Reference yield:

: 120-92-3
cyclopentanone

: 50670-55-8
4-(4-cyanophenyl)-benzaldehyde

: 1380049-02-4
4'-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}-1,1'-biphenyl-4-carbonitrile

: C₁₉H₁₇NO₂

Guidance literature:: With Pd nanoparticle encapsulated proline decorated bifunctional NH₂-UiO-66 metal organic framework; In water; at -20 ℃; for 120h; Reagent/catalyst; Overall yield = 68 percent; enantioselective reaction;
DOI:10.1021/acs.inorgchem.0c00065

Reference yield:

: 3058-39-7
4-iodobenzonitrile

: 87199-17-5
4-formylphenylboronic acid,

: 1380049-02-4
4'-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}-1,1'-biphenyl-4-carbonitrile

: C₁₉H₁₇NO₂

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / ethanol; water / 0.17 h / 80 °C

2: Pd nanoparticle encapsulated proline decorated bifunctional NH₂-UiO-66 metal organic framework / water / 120 h / -20 °C

With potassium carbonate; In ethanol; water; 1: |Suzuki Coupling;
DOI:10.1021/acs.inorgchem.0c00065