N-(fluoren-9-ylmethyloxycarbonyl)-4-(O,O'-dibenzyl-phosphonocarbonyl)-L-phenylalanine methyl ester

Base Information

Chemical Name:N-(fluoren-9-ylmethyloxycarbonyl)-4-(O,O'-dibenzyl-phosphonocarbonyl)-L-phenylalanine methyl ester
CAS No.:1404459-19-3
Molecular Formula:C₄₀H₃₆NO₈P
Molecular Weight:689.701
Hs Code.:

Synonyms:N-(fluoren-9-ylmethyloxycarbonyl)-4-(O,O'-dibenzyl-phosphonocarbonyl)-L-phenylalanine methyl ester

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Chemical Property of N-(fluoren-9-ylmethyloxycarbonyl)-4-(O,O'-dibenzyl-phosphonocarbonyl)-L-phenylalanine methyl ester

Chemical Property:

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Technology Process of N-(fluoren-9-ylmethyloxycarbonyl)-4-(O,O'-dibenzyl-phosphonocarbonyl)-L-phenylalanine methyl ester

There total 8 articles about N-(fluoren-9-ylmethyloxycarbonyl)-4-(O,O'-dibenzyl-phosphonocarbonyl)-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-4-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid

: 1404459-19-3
N-(fluoren-9-ylmethyloxycarbonyl)-4-(O,O'-dibenzyl-phosphonocarbonyl)-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.58 h / 0 - 20 °C / Inert atmosphere

2: toluene / 3 h / 50 °C / Inert atmosphere

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201201475

Reference yield:

: 15205-57-9
tribenzyl phosphite

: C₂₆H₂₂ClNO₅

: 1404459-19-3
N-(fluoren-9-ylmethyloxycarbonyl)-4-(O,O'-dibenzyl-phosphonocarbonyl)-L-phenylalanine methyl ester

Guidance literature:: In toluene; at 50 ℃; for 3h; Inert atmosphere;
DOI:10.1002/anie.201201475

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1404459-19-3
N-(fluoren-9-ylmethyloxycarbonyl)-4-(O,O'-dibenzyl-phosphonocarbonyl)-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

2.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / water; N,N-dimethyl-formamide / 0.17 h / 70 °C

2.2: 3 h / 70 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.2: 3.25 h / 0 - 20 °C / Inert atmosphere

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.58 h / 0 - 20 °C / Inert atmosphere

5.1: toluene / 3 h / 50 °C / Inert atmosphere

With oxalyl dichloride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201201475