Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-2-O-chloroacetyl-1-thio-α-D-mannopyranoside

Base Information

Chemical Name:Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-2-O-chloroacetyl-1-thio-α-D-mannopyranoside
CAS No.:220679-79-8
Molecular Formula:C₂₃H₃₇ClO₆SSi
Molecular Weight:505.148
Hs Code.:

Synonyms:Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-2-O-chloroacetyl-1-thio-α-D-mannopyranoside

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Chemical Property of Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-2-O-chloroacetyl-1-thio-α-D-mannopyranoside

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Technology Process of Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-2-O-chloroacetyl-1-thio-α-D-mannopyranoside

There total 12 articles about Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-2-O-chloroacetyl-1-thio-α-D-mannopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 220679-86-7
Chloro-acetic acid (2R,3S,4S,5R,6R)-5-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-2-ethylsulfanyl-4-trimethylsilanyloxy-tetrahydro-pyran-3-yl ester

: 220679-79-8
Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-2-O-chloroacetyl-1-thio-α-D-mannopyranoside

Guidance literature:: With hydrogen fluoride; water; In acetonitrile;
DOI:10.1002/(SICI)1521-3773(19981231)37:24<3423::AID-ANIE3423>3.0.CO;2-I

Reference yield:

: (2R,3S,4R,5S,6R)-5-Benzyloxy-2-ethylsulfanyl-6-hydroxymethyl-tetrahydro-pyran-3,4-diol

: 220679-79-8
Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-2-O-chloroacetyl-1-thio-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / tetrahydrofuran / 2 h / 20 °C

2: NEt₃ / CH₂Cl₂ / 3 h / -78 - 20 °C

3: pyridine / CH₂Cl₂ / 1 h / -5 °C

4: HF; H₂O / acetonitrile / 0.5 h / 20 °C

With pyridine; 1H-imidazole; hydrogen fluoride; water; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Etherification / 2: Etherification / 3: Acylation / 4: Desilylation;

Reference yield:

: 220679-85-6
Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-1-thio-α-D-mannopyranoside

: 220679-79-8
Ethyl 4-O-benzyl-6-O-tert-butyldimethylsilyl-2-O-chloroacetyl-1-thio-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃ / CH₂Cl₂ / 3 h / -78 - 20 °C

2: pyridine / CH₂Cl₂ / 1 h / -5 °C

3: HF; H₂O / acetonitrile / 0.5 h / 20 °C

With pyridine; hydrogen fluoride; water; triethylamine; In dichloromethane; acetonitrile; 1: Etherification / 2: Acylation / 3: Desilylation;