1-[methyl(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)nitroryl]cyclopentanecarboxylic acid

Base Information

Chemical Name:1-[methyl(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)nitroryl]cyclopentanecarboxylic acid
CAS No.:1355158-43-8
Molecular Formula:C₃₀H₂₈F₃N₃O₄
Molecular Weight:551.565
Hs Code.:

Synonyms:1-[methyl(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)nitroryl]cyclopentanecarboxylic acid

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Chemical Property of 1-[methyl(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)nitroryl]cyclopentanecarboxylic acid

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Technology Process of 1-[methyl(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)nitroryl]cyclopentanecarboxylic acid

There total 10 articles about 1-[methyl(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)nitroryl]cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

: 1355157-93-5
1-((4-(5-(2-(methoxymethyl)-2'-methylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl)benzyl)(methyl)amino)cyclopentanecarboxylic acid

: 1355158-43-8
1-[methyl(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)nitroryl]cyclopentanecarboxylic acid

Guidance literature:: With m-chloroperoxybenzoic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 874-89-5
4-Cyanobenzyl alcohol

: 1355158-43-8
1-[methyl(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)nitroryl]cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine / ethanol; water / 16 h / 74 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 18 h / 20 °C / Microwave irradiation

3: manganese(IV) oxide / 1,4-dioxane / 70 °C

4: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 20 °C

5: m-chloroperoxybenzoic acid / dichloromethane / 1 h / 20 °C

With manganese(IV) oxide; m-chloroperoxybenzoic acid; hydroxylamine; sodium cyanoborohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 142031-67-2
methyl 4-bromo-3-(bromomethyl)benzoate

: 1355158-43-8
1-[methyl(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)nitroryl]cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 96 h / Reflux

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / Inert atmosphere; Reflux

3.1: sodium hydroxide / ethanol / 1 h / 60 °C

3.2: pH 2

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 18 h / 20 °C / Microwave irradiation

5.1: manganese(IV) oxide / 1,4-dioxane / 70 °C

6.1: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 20 °C

7.1: m-chloroperoxybenzoic acid / dichloromethane / 1 h / 20 °C

With manganese(IV) oxide; m-chloroperoxybenzoic acid; sodium cyanoborohydride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; acetonitrile;