trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide

Base Information

Chemical Name:trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide
CAS No.:161277-14-1
Molecular Formula:C₂₁H₂₉N₂O₅P
Molecular Weight:420.445
Hs Code.:

Synonyms:trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide

Suppliers and Price of trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide

There total 13 articles about trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-1-<(methylsulfonyl)oxy>ethyl>cyclobutane-1-N,N-pentamethylenecarboxamide

: 161277-14-1
trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1021/jm00051a005

Reference yield:

: 117488-02-5
cis-1-Azido-N,N-pentamethylene-3-(phenylsulfonyl)cyclobutane-1-carboxamide

: 161277-14-1
trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: H₂ / Pd/C / ethyl acetate / 20 h / 760 Torr

2: 96 percent / Heating

3: Et₃N / 1 h / 0 - 20 °C

4: 1.) BuLi / 1.) THF, -40 deg C - -50 deg C, 1 h, 2.) THF, -50 deg C, - RT

5: 1.5 g / sodium amalgam / tetrahydrofuran; methanol / 3 h / Ambient temperature

6: tetrahydrofuran; diethyl ether

7: 1.) BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, a) -78 deg C, 40 min, b.) 1 h

8: 93 percent / NaBH₄ / ethanol / 0.25 h / Ambient temperature

9: Et₃N / CH₂Cl₂ / 20 h

10: 93 percent / BuLi / tetrahydrofuran / 3 h / -78 °C

With sodium tetrahydroborate; sodium amalgam; n-butyllithium; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00051a005

Reference yield:

: 161181-43-7
1-Azido-3-benzenesulfonyl-cyclobutanecarbonyl chloride

: 161277-14-1
trans-1-(benzoylamino)-3-<2-(dimethoxyphosphoryl)-ethenyl>cyclobutane-1-N,N-pentamethylenecarboxamide

Guidance literature:: Multi-step reaction with 11 steps

1: CH₂Cl₂ / 1 h / Ambient temperature

2: H₂ / Pd/C / ethyl acetate / 20 h / 760 Torr

3: 96 percent / Heating

4: Et₃N / 1 h / 0 - 20 °C

5: 1.) BuLi / 1.) THF, -40 deg C - -50 deg C, 1 h, 2.) THF, -50 deg C, - RT

6: 1.5 g / sodium amalgam / tetrahydrofuran; methanol / 3 h / Ambient temperature

7: tetrahydrofuran; diethyl ether

8: 1.) BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, a) -78 deg C, 40 min, b.) 1 h

9: 93 percent / NaBH₄ / ethanol / 0.25 h / Ambient temperature

10: Et₃N / CH₂Cl₂ / 20 h

11: 93 percent / BuLi / tetrahydrofuran / 3 h / -78 °C

With sodium tetrahydroborate; sodium amalgam; n-butyllithium; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00051a005