tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate
CAS No.:1603845-37-9
Molecular Formula:C₂₉H₃₄N₈O₅
Molecular Weight:574.64
Hs Code.:

Synonyms:tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate

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Chemical Property of tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate

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Technology Process of tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate

There total 7 articles about tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 39684-80-5
2-(tert-butoxycarbonylamino)ethyl bromide

: 1603845-36-8
3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1603845-37-9
tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmcl.2015.04.103

Reference yield:

: 1603845-34-6
C₂₁H₂₄FN₇O₄

: 1603845-37-9
tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate

2: trifluoroacetic acid / dichloromethane

3: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 330793-48-1
4-(4-amino-3-iodopyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1603845-37-9
tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 80 °C

2: potassium carbonate

3: trifluoroacetic acid / dichloromethane

4: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;