methyl (8R,9S,2'S,3'S,2E,4Z,6E)-9,10-epoxy-8-[2'-(9-fluorenylmethylcarbamino)-3'-phenylbutanoyloxy]-9-methyl-2,4,6-decatrienoate

Base Information

Chemical Name:methyl (8R,9S,2'S,3'S,2E,4Z,6E)-9,10-epoxy-8-[2'-(9-fluorenylmethylcarbamino)-3'-phenylbutanoyloxy]-9-methyl-2,4,6-decatrienoate
CAS No.:247175-70-8
Molecular Formula:C₃₇H₃₇NO₇
Molecular Weight:607.703
Hs Code.:

Synonyms:methyl (8R,9S,2'S,3'S,2E,4Z,6E)-9,10-epoxy-8-[2'-(9-fluorenylmethylcarbamino)-3'-phenylbutanoyloxy]-9-methyl-2,4,6-decatrienoate

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Chemical Property of methyl (8R,9S,2'S,3'S,2E,4Z,6E)-9,10-epoxy-8-[2'-(9-fluorenylmethylcarbamino)-3'-phenylbutanoyloxy]-9-methyl-2,4,6-decatrienoate

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Technology Process of methyl (8R,9S,2'S,3'S,2E,4Z,6E)-9,10-epoxy-8-[2'-(9-fluorenylmethylcarbamino)-3'-phenylbutanoyloxy]-9-methyl-2,4,6-decatrienoate

There total 4 articles about methyl (8R,9S,2'S,3'S,2E,4Z,6E)-9,10-epoxy-8-[2'-(9-fluorenylmethylcarbamino)-3'-phenylbutanoyloxy]-9-methyl-2,4,6-decatrienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 113932-09-5
methyl (8R,9S,2E,4Z,6E)-9,10-epoxy-8-hydroxy-9-methyl-2,4,6-decatrienoate

: 247175-69-5,1214028-21-3
N-(9-fluorenylmethoxycarbonyl)-(2S,3S)-erythro-L-β-methylphenylalanine

: 247175-70-8
methyl (8R,9S,2'S,3'S,2E,4Z,6E)-9,10-epoxy-8-[2'-(9-fluorenylmethylcarbamino)-3'-phenylbutanoyloxy]-9-methyl-2,4,6-decatrienoate

Guidance literature:: With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1271/bbb.63.1253

Reference yield:

: 25488-25-9,134235-83-9
(2S,3S)-methylphenylalanine

: 247175-70-8
methyl (8R,9S,2'S,3'S,2E,4Z,6E)-9,10-epoxy-8-[2'-(9-fluorenylmethylcarbamino)-3'-phenylbutanoyloxy]-9-methyl-2,4,6-decatrienoate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. Na₂CO₃ / dioxane / 20 °C

2: 96 percent / 4-pyrrolidinopyridine; DCC / ethyl acetate / 2 h / 20 °C

With sodium carbonate; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate; 1: Condensation / 2: Condensation;
DOI:10.1271/bbb.63.1253

Reference yield:

: 102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate

: 247175-70-8
methyl (8R,9S,2'S,3'S,2E,4Z,6E)-9,10-epoxy-8-[2'-(9-fluorenylmethylcarbamino)-3'-phenylbutanoyloxy]-9-methyl-2,4,6-decatrienoate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. Na₂CO₃ / dioxane / 20 °C

2: 96 percent / 4-pyrrolidinopyridine; DCC / ethyl acetate / 2 h / 20 °C

With sodium carbonate; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate; 1: Condensation / 2: Condensation;
DOI:10.1271/bbb.63.1253