17alpha-Phenylestradiol

Base Information

• Chemical Name: 17alpha-Phenylestradiol
• CAS No.: 128075-88-7
• Molecular Formula: C₂₄H₂₈O₂
• Molecular Weight: 348.485
• Mol file: 128075-88-7.mol

Synonyms:17alpha-Phenylestradiol

Chemical Property of 17alpha-Phenylestradiol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 17alpha-Phenylestradiol

There total 5 articles about 17alpha-Phenylestradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

Estrone (53-16-7) + phenyllithium (591-51-5) → 17alpha-Phenylestradiol (128075-88-7)

Guidance literature:

In tetrahydrofuran; diethyl ether; cyclohexane; for 5h;

DOI:10.1021/jm0001166

Reference yield:

(8R,9S,13S,14S,17R)-3-(tert-Butyl-dimethyl-silanyloxy)-13-methyl-17-phenyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol → 17alpha-Phenylestradiol (128075-88-7)

Guidance literature:

With trimethylsilyl iodide; In tetrahydrofuran; diethyl ether; benzene; for 3h; Yield given; Ambient temperature;

DOI:10.1021/jm00095a006

Reference yield:

(8R,9S,13S,14S,17R)-3-(1-Methoxy-1-methyl-ethoxy)-13-methyl-17-phenyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol → 17alpha-Phenylestradiol (128075-88-7)

Guidance literature:

With methanol; acetyl chloride; In ethyl acetate;

DOI:10.1021/jm00003a005

upstream raw materials:

Estrone

phenyllithium

3-(O-tert-butyl(dimethyl)silyl)estrone