Furan-2-carboxylic acid benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-yl)-amide

Base Information

• Chemical Name: Furan-2-carboxylic acid benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-yl)-amide
• CAS No.: 117523-83-8
• Molecular Formula: C₂₄H₂₄N₄O₂S
• Molecular Weight: 432.546
• Mol file: 117523-83-8.mol

Synonyms:Furan-2-carboxylic acid benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-yl)-amide

Chemical Property of Furan-2-carboxylic acid benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Furan-2-carboxylic acid benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-yl)-amide

There total 4 articles about Furan-2-carboxylic acid benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-furancarbonyl chloride (527-69-5) + 1-phenethyl-4-piperidine (117523-90-7) → Furan-2-carboxylic acid benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-yl)-amide (117523-83-8)

Guidance literature:

With triethylamine; In chloroform; for 0.5h; Ambient temperature;

DOI:10.1021/jm00123a028

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) → Furan-2-carboxylic acid benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-yl)-amide (117523-83-8)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid / toluene / 96 h / Heating

2: NaBH₄ / methanol / 2 h / Heating

3: 60 percent / Et₃N / CHCl₃ / 0.5 h / Ambient temperature

With sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; In methanol; chloroform; toluene;

DOI:10.1021/jm00123a028

Reference yield:

4-Amino-2,1,3-benzothiadiazole (767-64-6) → Furan-2-carboxylic acid benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-yl)-amide (117523-83-8)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid / toluene / 96 h / Heating

2: NaBH₄ / methanol / 2 h / Heating

3: 60 percent / Et₃N / CHCl₃ / 0.5 h / Ambient temperature

With sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; In methanol; chloroform; toluene;

DOI:10.1021/jm00123a028

upstream raw materials:

2-furancarbonyl chloride

1-phenethyl-4-piperidine

1-(2-phenylethyl)-4-piperidinone

4-Amino-2,1,3-benzothiadiazole