Technology Process of (2R,3aR,6aR)-benzyl 2-(2,2,2-trifluoro-N-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)acetamido)octahydropentalene-3a-carboxylate
There total 11 articles about (2R,3aR,6aR)-benzyl 2-(2,2,2-trifluoro-N-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)acetamido)octahydropentalene-3a-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -50 °C
1.2: 2 h / -50 - -20 °C
2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 4 h / 110 °C / Reflux
3.1: sodium hydroxide; hydroxylamine hydrochloride / methanol; water / 8 h / 65 °C
4.1: dichloromethane / 1 h / 20 °C
4.2: 2 h / 0 °C
5.1: sodium hydroxide; water / methanol / 4 h / 20 °C
6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 16 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
With
dmap; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; tri-n-butyl-tin hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; t-butyldimethylsiyl triflate / dichloromethane / 20 °C
1.2: 0 - 20 °C
2.1: dichloromethane / 1 h / 20 °C
2.2: 2 h / 0 °C
3.1: sodium hydroxide; water / methanol / 4 h / 20 °C
4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 16 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
With
dmap; t-butyldimethylsiyl triflate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
methanol; dichloromethane;
