(2R,3aR,6aR)-benzyl 2-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate

Base Information

Chemical Name:(2R,3aR,6aR)-benzyl 2-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate
CAS No.:1461685-55-1
Molecular Formula:C₂₂H₃₁NO₄
Molecular Weight:373.492
Hs Code.:

Synonyms:(2R,3aR,6aR)-benzyl 2-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate

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Chemical Property of (2R,3aR,6aR)-benzyl 2-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate

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Technology Process of (2R,3aR,6aR)-benzyl 2-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate

There total 10 articles about (2R,3aR,6aR)-benzyl 2-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1461685-52-8
(2R,3aR,6aR)-2-((3S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1461685-55-1
(2R,3aR,6aR)-benzyl 2-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1461685-51-7
(2R,3aR,6aR)-methyl 2-((3S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate

: 1461685-55-1
(2R,3aR,6aR)-benzyl 2-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol / 4 h / 20 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 16 h / 20 °C

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane;

Reference yield:

: 851916-44-4
(1R,4S)-methyl 4-(2,5-dimethyl-1H-pyrrol-1-yl)cyclopent-2-enecarboxylate

: 1461685-55-1
(2R,3aR,6aR)-benzyl 2-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)octahydropentalene-3a-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -50 °C

1.2: 2 h / -50 - -20 °C

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 4 h / 110 °C / Reflux

3.1: sodium hydroxide; hydroxylamine hydrochloride / methanol; water / 8 h / 65 °C

4.1: dichloromethane / 1 h / 20 °C

4.2: 2 h / 0 °C

5.1: sodium hydroxide; water / methanol / 4 h / 20 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 16 h / 20 °C

With dmap; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; tri-n-butyl-tin hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; toluene;