4-(3-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl

Base Information

Chemical Name:4-(3-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl
CAS No.:1361392-04-2
Molecular Formula:C₂₆H₂₆F₂O₄S
Molecular Weight:472.553
Hs Code.:

Synonyms:4-(3-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl

Chemical Property:

Purity/Quality:

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Technology Process of 4-(3-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl

There total 4 articles about 4-(3-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361392-02-0
2-(3-(benzyloxy)cyclohexyloxy)-5-bromo-1,3-difluorobenzene

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1361392-04-2
4-(3-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 100 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 100-39-0
benzyl bromide

: 1361392-04-2
4-(3-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 - 20 °C

1.2: 3 h / 50 °C

1.3: 2 h / 60 °C

2.1: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / Microwave irradiation

With sodium hydride; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 114737-99-4,114738-00-0,116565-12-9,116565-13-0,137331-23-8
(1S^*,3R^*)-3-<(phenylmethyl)oxy>cyclohexanol

: 1361392-04-2
4-(3-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / Microwave irradiation

With caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water;