(13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Base Information

Chemical Name:(13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone
CAS No.:1381808-97-4
Molecular Formula:C₃₅H₅₂N₄O₈
Molecular Weight:656.82
Hs Code.:

(13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Synonyms:(13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

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Chemical Property of (13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

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Technology Process of (13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

There total 12 articles about (13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381816-66-5
C₄₁H₆₆N₄O₈Si

: 1381808-97-4
(13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1381812-59-4
(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

: 1381808-97-4
(13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 18 h / 20 °C

3.1: Grubbs catalyst first generation / dichloromethane / 42 h / Reflux; Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1381812-63-0
(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

: 1381808-97-4
(13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 2 steps

1: Grubbs catalyst first generation / dichloromethane / 42 h / Reflux; Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane;