(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

Base Information

Chemical Name:(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester
CAS No.:1381812-63-0
Molecular Formula:C₄₃H₇₀N₄O₈Si
Molecular Weight:799.136
Hs Code.:

(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

Synonyms:(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

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Chemical Property of (S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

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Technology Process of (S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

There total 7 articles about (S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381810-76-9
((E)-(2S,3S,4S,5S)-3,5-dimethoxy-2,4-dimethyloct-6-enyloxymethyl)benzene

: 1381812-63-0
(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium 4,4′-di-tert-butylbiphenylide / tetrahydrofuran / -78 - -70 °C / Inert atmosphere

1.2: -70 °C

2.1: pyridine / 2 h / 0 - 20 °C / Inert atmosphere

3.1: ozone / dichloromethane / -78 °C

3.2: -78 - 20 °C / Inert atmosphere

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: sodium methylate; methanol / 20 °C / Inert atmosphere

6.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve

7.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1.5 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 18 h / 20 °C

With pyridine; methanol; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; sodium methylate; lithium 4,4′-di-tert-butylbiphenylide; benzotriazol-1-ol; ozone; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1381811-18-2
(E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienal

: 1381812-63-0
(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1.5 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 18 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1381812-59-4
(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

: 1381812-63-0
(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid (R)-1-methyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 18 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;