2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile

Base Information

Chemical Name:2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile
CAS No.:1448895-26-8
Molecular Formula:C₁₈H₁₀Br₂N₂
Molecular Weight:414.099
Hs Code.:

Synonyms:2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile

Suppliers and Price of 2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile

There total 6 articles about 2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1514925-24-6
2-(4′-bromophenyl)-7,8-dibromo-7,8,1,8a-tetrahydroazulene-1,1-dicarbonitrile

: 1448895-26-8
2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at 0 - 25 ℃; Inert atmosphere;
DOI:10.1021/jo4020326

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1448895-26-8
2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane / acetic acid / 72 h / 75 °C

2.1: triethylamine / dichloromethane / 4 h / -78 °C / Inert atmosphere

3.1: trityl tetrafluoroborate / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux

3.2: 2 h / 0 °C / Inert atmosphere; Reflux

4.1: bromine / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0 - 25 °C / Inert atmosphere

With bromine; trityl tetrafluoroborate; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetic acid; 1,2-dichloro-ethane; toluene; 1.1: |Knoevenagel Condensation;
DOI:10.1021/jo4020326

Reference yield:

: 26088-78-8
2-[1-(4-bromophenyl)ethylidene]malononitrile

: 1448895-26-8
2-(4-bromophenyl)-7-bromo-1,8a-dihydroazulene-1,1-dicarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 4 h / -78 °C / Inert atmosphere

2.1: trityl tetrafluoroborate / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux

2.2: 2 h / 0 °C / Inert atmosphere; Reflux

3.1: bromine / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0 - 25 °C / Inert atmosphere

With bromine; trityl tetrafluoroborate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo4020326