2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid pyridin-3-ylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid pyridin-3-ylmethyl ester
CAS No.:113795-23-6
Molecular Formula:C₃₀H₃₇NO₃
Molecular Weight:459.629
Hs Code.:

Synonyms:2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid pyridin-3-ylmethyl ester

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Chemical Property of 2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid pyridin-3-ylmethyl ester

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Technology Process of 2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid pyridin-3-ylmethyl ester

There total 8 articles about 2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid pyridin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 100-55-0
3-hydroxymethylpyridin

: 113795-14-5
2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid

: 113795-23-6
2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid pyridin-3-ylmethyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at -5 ℃;
DOI:10.1021/jm00401a022

Reference yield:

: 38841-95-1
1-(p-methoxyphenyl)-4-phenylbutane

: 113795-23-6
2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid pyridin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine hydrochloride / 4 h / 200 °C

2: NaH / tetrahydrofuran / 8 h / Heating

3: diisopropylamine, n-BuLi / tetrahydrofuran; hexane / 1.) 30 deg C, 30 min, 2.) room temperature, overnight

4: 44 percent / DCC / CH₂Cl₂ / -5 °C

With n-butyllithium; pyridine hydrochloride; sodium hydride; diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00401a022

Reference yield:

: 101594-58-5
1-(4-methoxyphenyl)-4-phenylbutan-1-one

: 113795-23-6
2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid pyridin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80percent hydrazine hydrate, 0.66 mol NaOH / bis-(2-hydroxy-ethyl) ether / 4 h / Heating

2: pyridine hydrochloride / 4 h / 200 °C

3: NaH / tetrahydrofuran / 8 h / Heating

4: diisopropylamine, n-BuLi / tetrahydrofuran; hexane / 1.) 30 deg C, 30 min, 2.) room temperature, overnight

5: 44 percent / DCC / CH₂Cl₂ / -5 °C

With sodium hydroxide; n-butyllithium; pyridine hydrochloride; sodium hydride; hydrazine hydrate; diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane; diethylene glycol;
DOI:10.1021/jm00401a022