2-(isopentyloxy)ethyl-3-(2-ethylhexanamido)-5-(2-(7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthamido)acetamido)benzoate

Base Information

Chemical Name:2-(isopentyloxy)ethyl-3-(2-ethylhexanamido)-5-(2-(7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthamido)acetamido)benzoate
CAS No.:1260632-48-1
Molecular Formula:C₆₀H₉₄N₄O₉
Molecular Weight:1015.43
Hs Code.:

Synonyms:2-(isopentyloxy)ethyl-3-(2-ethylhexanamido)-5-(2-(7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthamido)acetamido)benzoate

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Chemical Property of 2-(isopentyloxy)ethyl-3-(2-ethylhexanamido)-5-(2-(7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthamido)acetamido)benzoate

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Technology Process of 2-(isopentyloxy)ethyl-3-(2-ethylhexanamido)-5-(2-(7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthamido)acetamido)benzoate

There total 15 articles about 2-(isopentyloxy)ethyl-3-(2-ethylhexanamido)-5-(2-(7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthamido)acetamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1260632-36-7
2-(isopentyloxy)ethyl-3-(2-aminoacetamido)-5-(2-ethylhexanamido)benzoate

: 1260632-19-6
7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthoic acid

: 1260632-48-1
2-(isopentyloxy)ethyl-3-(2-ethylhexanamido)-5-(2-(7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthamido)acetamido)benzoate

Guidance literature:: 7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2h; Inert atmosphere;

2-(isopentyloxy)ethyl-3-(2-aminoacetamido)-5-(2-ethylhexanamido)benzoate; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol102522m

Reference yield:

: C₄₄H₇₄N₂O₄

: 1260632-48-1
2-(isopentyloxy)ethyl-3-(2-ethylhexanamido)-5-(2-(7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthamido)acetamido)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / methanol / 6 h

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ol102522m

Reference yield:

: C₂₀H₃₀N₂O₅

: 1260632-48-1
2-(isopentyloxy)ethyl-3-(2-ethylhexanamido)-5-(2-(7-((2-ethylhexyl)carbamoyl)-3,6-bis((2-ethylhexyl)oxy)-2-naphthamido)acetamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 10% palladium on activated charcoal; hydrogen / dichloromethane

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2.2: 24 h / Darkness

3.1: trifluoroacetic acid / dichloromethane / 3 h

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / Inert atmosphere

4.2: 24 h / 20 °C / Inert atmosphere

With 10% palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol102522m