trans-octahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1(2H)-naphthalenone

Base Information

Chemical Name:trans-octahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1(2H)-naphthalenone
CAS No.:80765-07-7
Molecular Formula:C₂₂H₃₂O₃
Molecular Weight:344.494
Hs Code.:

Synonyms:trans-octahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1(2H)-naphthalenone

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Chemical Property of trans-octahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1(2H)-naphthalenone

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Technology Process of trans-octahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1(2H)-naphthalenone

There total 5 articles about trans-octahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1(2H)-naphthalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 80765-06-6
trans-decahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1-naphthalenol

: 80765-07-7
trans-octahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1(2H)-naphthalenone

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 30 ℃; for 2h;
DOI:10.1021/jo00348a025

Reference yield:

: 60732-17-4
2,5-dimethoxybenzyl bromide

: 80765-07-7
trans-octahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Li / 1.) NH₃ (liquid), THF, 0.5 h, 2.) 15 min

2: 85 percent / dimethylsulfoxide / 40 h / 75 - 80 °C

3: 80 percent / H₂, methanol / 10percent Pd/C / triethylamine / 6 h / 30 °C / 760 Torr

4: 90 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / 30 °C

With methanol; hydrogen; lithium; pyridinium chlorochromate; palladium on activated charcoal; In dichloromethane; dimethyl sulfoxide; triethylamine;
DOI:10.1021/jo00348a025

Reference yield:

: 24138-10-1,26742-30-3,38405-15-1,52842-07-6,102058-65-1
(+/-)-(4aβ,5β)-4,4a,5,6,7,8-hexahydro-5-hydroxy-1,4a-dimethylnaphthalen-2(3H)-one

: 80765-07-7
trans-octahydro-5α-<(2,5-dimethoxyphenyl)methyl>-5β,6β,8aβ-trimethyl-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Li / 1.) NH₃ (liquid), THF, 0.5 h, 2.) 15 min

2: 85 percent / dimethylsulfoxide / 40 h / 75 - 80 °C

3: 80 percent / H₂, methanol / 10percent Pd/C / triethylamine / 6 h / 30 °C / 760 Torr

4: 90 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / 30 °C

With methanol; hydrogen; lithium; pyridinium chlorochromate; palladium on activated charcoal; In dichloromethane; dimethyl sulfoxide; triethylamine;
DOI:10.1021/jo00348a025