60732-17-4

Basic information

• Product Name: 2,5-Dimethoxybenzylbromide
• Synonyms: 2,5-Dimethoxybenzylbromide
• CAS NO: 60732-17-4
• Molecular Formula: C₉H₁₁BrO₂
• Molecular Weight: 231.0864
• Mol File: 60732-17-4.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 281.8 °C at 760 mmHg
• Flash Point: 122.4 °C
• Appearance: /
• Density: 1.384 g/cm³
• Vapor Pressure: 0.00596mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 2,5-Dimethoxybenzylbromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethoxybenzylbromide(60732-17-4)
• EPA Substance Registry System: 2,5-Dimethoxybenzylbromide(60732-17-4)

Safety Data

• Hazardous Substances Data: 60732-17-4(Hazardous Substances Data)

Usage

General Description

2,5-Dimethoxybenzylbromide is a chemical compound with the formula C9H11BrO2. It is a derivative of bromobenzene and contains two methoxy groups on the benzene ring. The compound is commonly used in organic synthesis as a reagent for the methylation of various functional groups, including alcohols and amines. It is a colorless to pale yellow liquid at room temperature and has a strong, pungent odor. 2,5-Dimethoxybenzylbromide is considered to be a hazardous chemical and should be handled with care due to its potential to cause skin and eye irritation.

InChI:InChI=1/C9H11BrO2/c1-11-8-3-4-9(12-2)7(5-8)6-10/h3-5H,6H2,1-2H3

Upstream product

• 558-13-4 carbon tetrabromide 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 
• 50-00-0 formaldehyd 
• 150-78-7 1,4-dimethoxybezene 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 95-71-6 2-methylbenzene-1,4-diol 
• 128-08-5 N-Bromosuccinimide 
• 24599-58-4 2,5-dimethoxy toluene 

Downstream Products

• 3275-95-4 2,5-dimethoxybenzylamine 
• 184485-48-1 (1S,2S,4aS)-(-)-trans-1α-[(2,5-dimethoxyphenyl)methyl]-5-(2-methyl-1,3-dioxolan-2-yl)-octahydro-1β,2β,4aβ-trimethyl-5(6H)-naphthalenone 
• 5273-75-6 2,5-dihydroxybenzyl mercaptan 
• 171366-64-6 2,5-dihydroxybenzyl thioacetate 
• 1758-25-4 (2,5-dimethoxyphenyl)acetic acid 
• 18086-24-3 2-(2,5-dimethoxyphenyl)acetonitrile 
• 103441-37-8 1,4-dimethoxy-2-methoxymethyl-benzene 
• 184485-46-9 (1S,4aS)-(+)-trans-1α-[(2,5-dimethoxyphenyl)methyl]-1β,4aβ-dimethyl-5-(2-methyl-1,3-dioxolan-2-yl)-hexahydro-2,5(3H,6H)-naphthalenedione 
• 137677-99-7 2,2'-(2,5,8,11-tetraoxadodecane-1,12-diyl)bis(1,4-dimethoxybenzene) 
• 33654-63-6 3-acetyl-4-(2', 5'-dimethoxyphenyl)-2-butanone 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 
• 80765-03-3 trans-octahydro-1α-<(2,5-dimethoxyphenyl)methyl>-1β,4aβ-dimethyl-5β-hydroxy-2(1H)-naphthalenone 
• 1199-08-2 ethylhydroquinone dimethyl ether 
• 20306-76-7 2,5,2',5'-tetramethoxy-bibenzyl 

Relevant articles and documents

Preparation method of 2,5-dimethoxyphenylacetic acid

The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of 2,5-dimethoxyphenylacetic acid, wherein the method comprises the following steps: A,reacting 1,4-dimethoxybenzene in a formylation system to obtain 2,5-dimethoxybenzaldehyde; B, reacting the 2,5-dimethoxybenzaldehyde obtained in the step A with a reducing agent, extracting a reaction system, then combining organic phases, drying, concentrating under reduced pressure and distilling a crude product to obtain 2,5-dimethoxybenzyl alcohol; C, reacting the 2,5-dimethoxybenzyl alcoholobtained in the step B with a bromination reagent to obtain 2-bromomethyl-1,4-dimethoxybenzene; and D, reacting the 2-bromomethyl-1,4-dimethoxybenzene obtained in the step C with magnesium or butyl lithium and carbon dioxide in a solvent to obtain the 2,5-dimethoxyphenylacetic acid. The yield and the total yield of the 2,5-dimethoxyphenylacetic acid obtained by the method disclosed by the invention are both higher than those of 2,5-dimethoxyphenylacetic acid synthesized by a Willegerdt-Kindler method.

Preparation method of 2, 5-dimethoxyphenylacetic acid

The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of 2, 5-dimethoxyphenylacetic acid, which comprises the following steps: A. Reacting 1,4-dimethoxybenzene with formaldehyde under the action of hydrogen halide, extracting by the reaction system, merging with organic phases, drying, concentrating under reduced pressure, and purifying the crude product to obtain 2-halon methyl-1, 4-dimethoxybenzene ; and B, under the protection of inert gas, putting the 2-halo methyl-1, 4-dimethoxybenzene obtained in the step A, magnesium or butyl lithium and carbon dioxide into a solvent, and then carrying out extraction and deactivation, reduced pressure distillation, extraction, organic phase combination and reduced pressure concentration toobtain the 2, 5-dimethoxyphenylacetic acid. The yield and the total yield of the 2, 5-dimethoxyphenylacetic acid obtained by the method disclosed by the invention are both higher than those of the 2,5-dimethoxyphenylacetic acid synthesized by a Willgerodt-Kindler method.

CD16A BINDING AGENTS AND USES THEREOF

Among other things, the present disclosure provides compounds, compositions thereof, and methods of using the same. In some embodiments, compounds of the present disclosure bind to Fc receptors, e.g., CD16a. In some embodiments, compounds of the present disclosure are useful for treating various conditions, disorders or diseases including cancer.