(1S,4S)-N-benzoyl-8-methoxy-1-methyl-2,3,4,5-tetrahydro-1,4-methano-3-benzazepine

Base Information

Chemical Name:(1S,4S)-N-benzoyl-8-methoxy-1-methyl-2,3,4,5-tetrahydro-1,4-methano-3-benzazepine
CAS No.:929641-34-9
Molecular Formula:C₂₀H₂₁NO₂
Molecular Weight:307.392
Hs Code.:

Synonyms:(1S,4S)-N-benzoyl-8-methoxy-1-methyl-2,3,4,5-tetrahydro-1,4-methano-3-benzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,4S)-N-benzoyl-8-methoxy-1-methyl-2,3,4,5-tetrahydro-1,4-methano-3-benzazepine

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Technology Process of (1S,4S)-N-benzoyl-8-methoxy-1-methyl-2,3,4,5-tetrahydro-1,4-methano-3-benzazepine

There total 14 articles about (1S,4S)-N-benzoyl-8-methoxy-1-methyl-2,3,4,5-tetrahydro-1,4-methano-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 929641-33-8
C₂₀H₂₃NO₃

: 929641-34-9
(1S,4S)-N-benzoyl-8-methoxy-1-methyl-2,3,4,5-tetrahydro-1,4-methano-3-benzazepine

Guidance literature:: With aluminium trichloride; In dichloromethane; at 20 ℃; for 27h;
DOI:10.1016/j.tet.2007.05.059

Reference yield:

: 1301725-81-4
C₂₀H₂₃NO₃

: 929641-34-9
(1S,4S)-N-benzoyl-8-methoxy-1-methyl-2,3,4,5-tetrahydro-1,4-methano-3-benzazepine

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 20 ℃;
DOI:10.1002/ejoc.201100091

Reference yield:

: 98-88-4
benzoyl chloride

: 929641-34-9
(1S,4S)-N-benzoyl-8-methoxy-1-methyl-2,3,4,5-tetrahydro-1,4-methano-3-benzazepine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 76 percent / sodium hydroxide / H₂O; diethyl ether / 24 h

2.1: 90 percent / acetic anhydride / 5 h / 90 °C

3.1: Mg / tetrahydrofuran

3.2: 27 percent / tetrahydrofuran / -10 °C

4.1: 62 percent / trifluoroacetic acid; triethylsilane / 0 - 20 °C

5.1: 98 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

6.1: 39 percent / tetrahydrofuran / -78 °C

7.1: 76 percent / aluminum chloride / CH₂Cl₂ / 27 h / 20 °C

With triethylsilane; sodium hydroxide; aluminium trichloride; oxalyl dichloride; acetic anhydride; magnesium; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; 5.1: Swern oxidation;
DOI:10.1016/j.tet.2007.05.059