3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide

Base Information

Chemical Name:3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide
CAS No.:1621255-12-6
Molecular Formula:C₃₆H₃₆F₆N₂O₄
Molecular Weight:674.683
Hs Code.:

3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide

Synonyms:3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide

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Chemical Property of 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide

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Technology Process of 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide

There total 9 articles about 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₃₄ClF₆NO₄

: 1621255-12-6
3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; water; for 0.0833333h;

Reference yield:

: 1423044-99-8
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

: 1621255-12-6
3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

2: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

3: lithium hydroxide monohydrate; water / 1,4-dioxane / 4 h / 50 °C

4: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 4 h / Reflux

5: ammonium hydroxide / water; tetrahydrofuran / 0.08 h

With ammonium hydroxide; thionyl chloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); lithium hydroxide monohydrate; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 2: |Suzuki Coupling;

Reference yield:

: 1402798-74-6
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

: 1621255-12-6
3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-methylbiphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

2: lithium hydroxide monohydrate; water / 1,4-dioxane / 4 h / 50 °C

3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 4 h / Reflux

4: ammonium hydroxide / water; tetrahydrofuran / 0.08 h

With ammonium hydroxide; thionyl chloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); lithium hydroxide monohydrate; water; sodium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 1: |Suzuki Coupling;