4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate

Base Information

Chemical Name:4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate
CAS No.:278597-81-2
Molecular Formula:C₃₂H₄₃N₃O₈
Molecular Weight:597.709
Hs Code.:

Synonyms:4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate

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Chemical Property of 4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate

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Technology Process of 4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate

There total 1 articles about 4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 110-91-8,99108-56-2
morpholine

: 278597-79-8
tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate

: 32315-10-9
bis(trichloromethyl) carbonate

: 278597-81-2
4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate

Guidance literature:: tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate; bis(trichloromethyl) carbonate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 4h;

morpholine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; for 18h;

Reference yield: 90.0%

: 278597-81-2
4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate

: 278598-66-6
(2S)-2-[((2S)-2-{[(Benzyloxy)carbonyl]amino}-4-methylpentanoyl) amino]-3-{4-[(4-morpholinylcarbonyl)oxy]phenyl}propanoic acid

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 4h;

Reference yield: 87.0%

: 278597-81-2
4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate

: 4-[(2S)-2-{[(2S)-2-Amino-4-methylpentanoyl]amino}-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate hydrochloride

Guidance literature:: 4-[(2S)-2-[((2S)-2-{[(Benzyloxy) carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-morpholinecarboxylate; With ammonium formate; 10% palladium on activated carbon; In ethanol; at 20 ℃; for 17h;

With hydrogenchloride; In diethyl ether; dichloromethane;