tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate

Base Information

Chemical Name:tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate
CAS No.:278597-79-8
Molecular Formula:C₂₇H₃₆N₂O₆
Molecular Weight:484.593
Hs Code.:

Synonyms:tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate

Suppliers and Price of tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate

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Chemical Property of tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate

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Technology Process of tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate

There total 1 articles about tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2018-66-8
Z-Leu-OH

: 16874-12-7,87553-74-0
Tyr(tBu)

: 278597-79-8
tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate

Guidance literature:: Z-Leu-OH; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 0.5h;

Tyr(tBu); In acetonitrile; for 18h;

Reference yield: 99.0%

: 13889-98-0
N-acetylpiperidine

: 278597-79-8
tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate

: 32315-10-9
bis(trichloromethyl) carbonate

: 4-[(2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(tert-butoxy)-3-oxopropyl]phenyl 4-acetyl-1-piperazine carboxylate

Guidance literature:: tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate; bis(trichloromethyl) carbonate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; at 20 ℃; for 4h;

N-acetylpiperidine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; for 18h;

Reference yield: 94.0%

: 278597-79-8
tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate

: 19271-90-0
(2-tert-butyl-phenoxy)-acetic acid

: 278597-91-4
tert-butyl (2S)-2-{[(2S)-2-({2-[2-(tert-butyl)phenoxy]acetyl}amino)-4-methylpentanoyl]amino}-3-(4-hydroxyphenyl)propanoate

Guidance literature:: tert-butyl (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]-3-(4-hydroxyphenyl)propanoate; With ammonium formate; 10% palladium on activated carbon; In ethanol; at 20 ℃; for 2h;

(2-tert-butyl-phenoxy)-acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); acetonitrile; at 20 ℃; for 18h;