N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodobenzamide

Base Information

• Chemical Name: N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodobenzamide
• CAS No.: 872337-78-5
• Molecular Formula: C₁₉H₁₉IN₄O
• Molecular Weight: 446.291
• Mol file: 872337-78-5.mol

Synonyms:N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodobenzamide

Chemical Property of N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodobenzamide

There total 4 articles about N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

2-Iodobenzoyl chloride (609-67-6) + 4-[2-(dimethylamino)ethyl]cinnoline (658710-34-0) → N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodobenzamide (872337-78-5)

Guidance literature:

With triethylamine; In dichloromethane; at 50 ℃; for 18h;

DOI:10.1016/j.bmc.2003.10.061

Reference yield:

4-chlorocinnoline (5152-84-1) → N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodobenzamide (872337-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 3 h / Heating

2: 33 percent / triethylamine / CH₂Cl₂ / 18 h / 50 °C

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2003.10.061

Reference yield:

2-Iodobenzoic acid (88-67-5) → N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodobenzamide (872337-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂ / 4 h / Heating

2: 33 percent / triethylamine / CH₂Cl₂ / 18 h / 50 °C

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2003.10.061

upstream raw materials:

2-Iodobenzoyl chloride

4-[2-(dimethylamino)ethyl]cinnoline

4-chlorocinnoline

2-Iodobenzoic acid