(3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate

Base Information

Chemical Name:(3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate
CAS No.:1613397-04-8
Molecular Formula:C₂HF₃O₂*C₂₀H₂₀ClF₃N₆O
Molecular Weight:566.891
Hs Code.:

Synonyms:(3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate

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Chemical Property of (3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate

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Technology Process of (3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate

There total 13 articles about (3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1613396-53-4
[(3S)-4-[[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]amino]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]-4-oxo-butyl]methanesulfonate

: 1613397-04-8
(3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at 70 ℃; for 3h;

Reference yield:

: 1613396-41-0
(3S)-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]tetrahydrofuran-2-one

: 1613397-04-8
(3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0 - 20 °C

2: triethylamine / dichloromethane / 0.5 h / 0 - 10 °C

3: triethylamine / 1,2-dichloro-ethane / 3 h / 70 °C

With trimethylaluminum; triethylamine; In dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 1613397-04-8
(3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium methylate / methanol; tert-butyl methyl ether / 0 - 20 °C / 1520.1 Torr

2.1: sodium hydroxide / methanol / 1 h / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1.08 h / 0 - 20 °C

4.1: sodium azide / acetone; water / 0.5 h / 0 - 20 °C

5.1: toluene / 1.5 h / 100 °C

5.2: 1 h / 20 - 100 °C

6.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0 - 20 °C

7.1: triethylamine / dichloromethane / 0.5 h / 0 - 10 °C

8.1: triethylamine / 1,2-dichloro-ethane / 3 h / 70 °C

With sodium azide; oxalyl dichloride; trimethylaluminum; sodium methylate; triethylamine; sodium hydroxide; In methanol; dichloromethane; tert-butyl methyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene;