2-amino-3-benzyl-5-ethynylpyrazine

Base Information

• Chemical Name: 2-amino-3-benzyl-5-ethynylpyrazine
• CAS No.: 1268631-69-1
• Molecular Formula: C₁₃H₁₁N₃
• Molecular Weight: 209.25
• Mol file: 1268631-69-1.mol

Synonyms:2-amino-3-benzyl-5-ethynylpyrazine

Chemical Property of 2-amino-3-benzyl-5-ethynylpyrazine

Chemical Property:

• Boiling Point: 394.4±42.0 °C(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)

Purity/Quality:

95+% ^*data from raw suppliers

3-Benzyl-5-ethynylpyrazin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-3-benzyl-5-ethynylpyrazine

There total 7 articles about 2-amino-3-benzyl-5-ethynylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-amino-3-benzyl-5-((trimethylsilyl)ethynyl)pyrazine → 2-amino-3-benzyl-5-ethynylpyrazine (1268631-69-1)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 2h;

DOI:10.1039/c6ob00659k

Reference yield:

C19H25N3Si → 2-amino-3-benzyl-5-ethynylpyrazine (1268631-69-1)

Guidance literature:

With tetrabutyl ammonium fluoride;

DOI:10.1016/j.tet.2010.12.001

Reference yield:

2-amino-5-bromo-3-phenylmethylpyrazine (174680-55-8) → 2-amino-3-benzyl-5-ethynylpyrazine (1268631-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; triethylamine / toluene / 9 h / 40 °C

2: potassium carbonate / methanol / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; triphenylphosphine; In methanol; toluene;

DOI:10.1039/c6ob00659k

upstream raw materials:

5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine

C₁₈H₁₇N₃O₃S

5-N-(p-toluenesulfonyl)amide-6-benzyl-2-O-trifluoromethanesulfonyloxy-pyrazine

2-amino-5-bromo-3-phenylmethylpyrazine