5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine

Base Information

• Chemical Name: 5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine
• CAS No.: 853941-51-2
• Molecular Formula: C₁₂H₁₀F₃N₃O₃S
• Molecular Weight: 333.291
• Mol file: 853941-51-2.mol

Synonyms:5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine

Chemical Property of 5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine

There total 2 articles about 5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-N-(p-toluenesulfonyl)amide-6-benzyl-2-O-trifluoromethanesulfonyloxy-pyrazine (671240-61-2) → 5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine (853941-51-2)

Guidance literature:

With sulfuric acid; at 0 ℃; for 0.5h;

DOI:10.3987/COM-05-10351

Reference yield:

C18H17N3O3S (671240-60-1) → 5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine (853941-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: sulfuric acid / 0 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.tet.2010.12.001

Reference yield: 97.0%

5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine (853941-51-2) + phenylacetylene (536-74-3) → 2-amino-3-benzyl-5-(phenylethynyl)pyrazine (853941-53-4)

Guidance literature:

With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 120 ℃; for 1h;

DOI:10.3987/COM-05-10351

upstream raw materials:

5-N-(p-toluenesulfonyl)amide-6-benzyl-2-O-trifluoromethanesulfonyloxy-pyrazine

C₁₈H₁₇N₃O₃S

Downstream raw materials:

2-amino-5-(4-fluorophenyl)-3-phenylmethylpyrazine

2-amino-3-benzyl-5-(4-N,N-dimethylaminophenyl)pyrazine

2-amino-3-benzyl-5-(phenylethynyl)pyrazine

2-amino-3-benzyl-5-phenyl-pyrazine