Technology Process of 3-benzyloxy-17-oxo-16,17-secoestra-1,3,5(10)-triene-16-nitrile
There total 5 articles about 3-benzyloxy-17-oxo-16,17-secoestra-1,3,5(10)-triene-16-nitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
p-toluenesulfonyl chloride;
In
pyridine;
at 20 ℃;
for 3h;
DOI:10.1135/cccc20000077
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 81 percent / potassium carbonate / methanol; acetone / 8 h / Heating
2.1: (CH3)3COK / 2-methyl-propan-2-ol / 0.25 h / 20 °C
2.2: 89.5 percent / isopentyl nitrite / 2-methyl-propan-2-ol / 1 h
3.1: 98 percent / NaBH4; KOH / methanol; CH2Cl2; H2O / 0.67 h / Heating
4.1: 72 percent / TsCl / pyridine / 3 h / 20 °C
With
potassium hydroxide; sodium tetrahydroborate; potassium tert-butylate; potassium carbonate; p-toluenesulfonyl chloride;
In
pyridine; methanol; dichloromethane; water; acetone; tert-butyl alcohol;
1.1: Substitution / 2.1: Metallation / 2.2: Substitution / 3.1: Reduction / 4.1: Ring cleavage;
DOI:10.1135/cccc20000077
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (CH3)3COK / 2-methyl-propan-2-ol / 0.25 h / 20 °C
1.2: 89.5 percent / isopentyl nitrite / 2-methyl-propan-2-ol / 1 h
2.1: 98 percent / NaBH4; KOH / methanol; CH2Cl2; H2O / 0.67 h / Heating
3.1: 72 percent / TsCl / pyridine / 3 h / 20 °C
With
potassium hydroxide; sodium tetrahydroborate; potassium tert-butylate; p-toluenesulfonyl chloride;
In
pyridine; methanol; dichloromethane; water; tert-butyl alcohol;
1.1: Metallation / 1.2: Substitution / 2.1: Reduction / 3.1: Ring cleavage;
DOI:10.1135/cccc20000077
